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N- benzyl- N- methyl- 2- (7,8- dihydro- 7- (2- fluoroethyl)- 8- oxo- 2- phenyl- 9H- purin- 9- yl)acetamide

a PET imaging agent for the 18-kDa translocator protein

Also Known As:

(18F)FEDAC; N-benzyl-N-methyl-2-(7,8-dihydro-7-(2-(18F)fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl)acetamide

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - N-benzyl-N-methyl-2-(7,8-dihydro-7-(2-fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl)acetamide: 3
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        N-benzyl-N-methyl-2-(7,8-dihydro-7-(2-fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl)acetamide: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - N-benzyl-N-methyl-2-(7,8-dihydro-7-(2-fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl)acetamide: 3

Experts

1.	Zhang, Ming-Rong: 3 articles (08/2021 - 01/2012)
2.	Xie, Lin: 2 articles (01/2018 - 01/2012)
3.	Fang, Wei: 1 article (08/2021)
4.	Luo, Rui: 1 article (08/2021)
5.	Wang, Feng: 1 article (08/2021)
6.	Wang, Lei: 1 article (08/2021)
7.	Wang, Yan-Rong: 1 article (08/2021)
8.	Ye, Fei: 1 article (08/2021)
9.	Cheon, Gi Jeong: 1 article (01/2018)
10.	Chung, June-Key: 1 article (01/2018)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 08/01/2021 - "[18F]FEDAC uptake is reduced in the injured myocardium, consistent with mitochondrial dysfunction. " 08/01/2021 - "We also assessed the feasibility of [18F]FEDAC for the early detection of mitochondrial dysfunction associated with myocardial ischemia (MI). " 08/01/2021 - "This study aimed to evaluate the biodistribution and kinetics of [18F]FEDAC targeting the translocator protein TSPO in the myocardium, and to explore its use for the identification of mitochondrial dysfunction. " 08/01/2021 - "[18F]FEDAC translocator protein positron emission tomography-computed tomography for early detection of mitochondrial dysfunction secondary to myocardial ischemia."
2.	Myocardial Ischemia (Ischemic Heart Diseases) 08/01/2021 - "We also assessed the feasibility of [18F]FEDAC for the early detection of mitochondrial dysfunction associated with myocardial ischemia (MI). " 08/01/2021 - "[18F]FEDAC translocator protein positron emission tomography-computed tomography for early detection of mitochondrial dysfunction secondary to myocardial ischemia."
3.	Pneumonia (Pneumonitis) 01/01/2012 - "PET imaging of lung inflammation with [18F]FEDAC, a radioligand for translocator protein (18 kDa)."
4.	Inflammation (Inflammations) 01/01/2018 - "Conclusion:18F-FEDAC enabled the visualization of active inflammation sites in arthritic joints in a CIA model by targeting TSPO expression in activated macrophages. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)