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((5Z)5- (1,3- benzodioxol- 5- yl)methylene- 2- phenylamino- 3,5- dihydro- 4H- imidazol- 4- one)

structure in first source

Also Known As:

leucettine L41

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - ((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one): 3
  - Dioxoles
    - ((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one): 3

Experts

1.	Bazureau, Jean-Pierre: 2 articles (01/2018 - 03/2014)
2.	Carreaux, François: 2 articles (01/2018 - 03/2014)
3.	Limanton, Emmanuelle: 2 articles (01/2018 - 03/2014)
4.	Meijer, Laurent: 2 articles (01/2018 - 03/2014)
5.	Audrain, M: 1 article (01/2022)
6.	Braudeau, J: 1 article (01/2022)
7.	Cartier, N: 1 article (01/2022)
8.	Gu, Y: 1 article (01/2022)
9.	Janel, N: 1 article (01/2022)
10.	Lindberg, M F: 1 article (01/2022)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2022 - "We specifically reduced the phosphorylation level of tau while leaving Aβ42 levels unchanged using a DYRK1A protein kinase inhibitor, Leucettine L41, in an adeno-associated virus-based Alzheimer's disease (AAV-AD) rat model. " 03/01/2014 - "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease."
2.	Cognitive Dysfunction 01/01/2018 - "Treatment of the three DS models with the pharmacological DYRK1A inhibitor leucettine L41 leads to normalization of DYRK1A activity and corrects the novel object cognitive impairment observed in these models. "
3.	Osteosarcoma (Osteogenic Sarcoma) 03/01/2014 - "We here report that leucettine L41 triggers bona fide autophagy in osteosarcoma U-2 OS cells and immortalized mouse hippocampal HT22 cells, characterized by microtubule-associated protein light chain 3 membrane translocation and foci formation. "

Related Drugs and Biologics

1.	Protein Kinase Inhibitors
2.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
3.	Dyrk Kinases