EPZ005687

inhibits EZH2 protein; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Leukemia 12/01/2014 - "It is concluded that the EPZ005687 inhibites proliferation, induces apoptosis and cell cycle blocking in G1 phase in leukemia cells. "
2.	Breast Neoplasms (Breast Cancer) 10/15/2015 - "We explored the interactions of five novel, structurally similar EZH2 inhibitors (EPZ005687, EPZ-6438, UNC1999, GSK343 and GSK126) with P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2). "
3.	Pulmonary Arterial Hypertension 01/01/2018 - "In this article, we investigated the protective role and mechanism of EPZ005687 in transverse aortic constriction-induced pulmonary arterial hypertension in mice. "

1.	Member 1 Subfamily B ATP Binding Cassette Transporter
2.	Proteins (Proteins, Gene)
3.	GSK343
4.	GSK-2816126
5.	UNC1999