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TAK-683

has antineoplastic activity

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1683
      - Kisspeptins: 865
        TAK-683: 4
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kisspeptins: 865
      - TAK-683: 4
  - Neuropeptides: 6772
    - Kisspeptins: 865
      - TAK-683: 4

Experts

1.	Matsui, Hisanori: 4 articles (03/2018 - 11/2012)
2.	Kusaka, Masami: 2 articles (03/2018 - 07/2014)
3.	Masaki, Tsuneo: 2 articles (03/2018 - 07/2014)
4.	Nakata, Daisuke: 2 articles (03/2018 - 07/2014)
5.	Tanaka, Akira: 2 articles (03/2018 - 07/2014)
6.	Watanabe, Tatsuya: 2 articles (03/2018 - 07/2014)
7.	Matsumoto, Shin-ichi: 2 articles (07/2014 - 11/2013)
8.	Ohtaki, Tetsuya: 2 articles (07/2014 - 11/2013)
9.	Yamaguchi, Masashi: 2 articles (07/2014 - 11/2013)
10.	Asami, Taiji: 2 articles (11/2013 - 11/2012)

Related Diseases

1.

Prostatic Neoplasms (Prostate Cancer)

03/05/2018 - "Previous studies showed that continuous subcutaneous administration of TAK-448 or TAK-683 caused rapid and profound reductions in plasma testosterone levels in various species, including male healthy volunteers, suggesting their therapeutic potential as anti-prostate cancer agents. "
07/15/2014 - "In addition, TAK-683 reduced plasma prostate specific antigen (PSA) in the JDCaP androgen-dependent prostate cancer rat model. "
03/05/2018 - "Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one-month depots of TAK-448 and TAK-683, investigational kisspeptin analogs, in male rats and an androgen-dependent prostate cancer model."
11/14/2013 - "Compound 26 has led to the elucidation of investigational analogs TAK-683 and TAK-448, both of which have undergone clinical evaluation for hormone-dependent diseases such as prostate cancer."
11/01/2012 - "TAK-448 and TAK-683, investigational agents with potential utility in the treatment of prostate cancer, are potent low molecular weight metastin receptor agonists consisting of nine amino acids. "

Related Drugs and Biologics

1.	acetyl- tyrosyl(46)- hydroxypropyl(47)- threonyl(49)- azaglycyl(51)- methylarginyl(53)- tryptophyl(54)- metastin (46-54)
2.	Kisspeptins
3.	Androgens
4.	Testosterone (Sustanon)
5.	Prostate-Specific Antigen (Semenogelase)
6.	Hormones (Hormone)
7.	Amino Acids
8.	3- (5- nitrofuryl)- 7- (5- nitrofurfurylidene)- 3,3a,4,5,6,7- hexahydro- 2H- indazole