3- (hydroxymethyl)- 4- (5- methylpyridin- 2- yl)- N- (6- (2,2,2- trifluoroethoxy)pyridin- 3- yl)- 3,4- dihydro- 2H- benzo(b)(1,4)oxazine- 8- carboxamide

a TRPV1 antagonist; structure in first source

Also Known As:

JTS-653

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-3,4-dihydro-2H-benzo(b)(1,4)oxazine-8-carboxamide: 2
  - Oxazines: 9
    - Benzoxazines: 58
      - 3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-3,4-dihydro-2H-benzo(b)(1,4)oxazine-8-carboxamide: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazines: 58
      - 3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-3,4-dihydro-2H-benzo(b)(1,4)oxazine-8-carboxamide: 2

Experts

1.	Hamada, Yuji: 2 articles (01/2013 - 08/2012)
2.	Kitagawa, Yoshihiro: 2 articles (01/2013 - 08/2012)
3.	Matsushita, Mutsuyoshi: 2 articles (01/2013 - 08/2012)
4.	Sakata, Masahiro: 2 articles (01/2013 - 08/2012)
5.	Usui, Kenji: 2 articles (01/2013 - 08/2012)
6.	Wada, Masashi: 2 articles (01/2013 - 08/2012)
7.	Tamai, Isao: 1 article (01/2013)
8.	Deai, Katsuya: 1 article (08/2012)
9.	Hayashi, Mikio: 1 article (08/2012)
10.	Koga, Yoshihisa: 1 article (08/2012)

Related Diseases

1.	Hyperalgesia 08/01/2012 - "JTS-653 significantly attenuated carrageenan-induced thermal hyperalgesia at 0.1 mg/kg p.o. " 08/01/2012 - "JTS-653 significantly prevented capsaicin-induced mechanical hyperalgesia at 1 mg/kg p.o. " 01/01/2013 - "JTS-653 partially attenuated mechanical hyperalgesia in the L5 spinal nerve ligation model in rats at 0.3 mg/kg, whereas indomethacin showed no effect. " 01/01/2013 - "The selective TRPV1 antagonist JTS-653 {(3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide} reversed mechanical hyperalgesia on day 7 after injection of complete-Freund-adjuvant into the hindpaw in rats at 0.3 mg/kg, whereas indomethacin showed no effect. "
2.	Chronic Pain 01/01/2013 - "Orally administered selective TRPV1 antagonist, JTS-653, attenuates chronic pain refractory to non-steroidal anti-inflammatory drugs in rats and mice including post-herpetic pain." 01/01/2013 - "JTS-653 reduced chronic pain at 0.3 mg/kg in herpes simplex virus-1-inoculated mice that has been reported as NSAID-refractory pain. "
3.	Intractable Pain 01/01/2013 - "JTS-653 reduced chronic pain at 0.3 mg/kg in herpes simplex virus-1-inoculated mice that has been reported as NSAID-refractory pain. "
4.	Pain (Aches) 01/01/2013 - "Orally administered selective TRPV1 antagonist, JTS-653, attenuates chronic pain refractory to non-steroidal anti-inflammatory drugs in rats and mice including post-herpetic pain." 01/01/2013 - "Both JTS-653 and indomethacin reduced formalin-induced pain in the second phase, whereas they showed no effect in the first phase. "
5.	Herpes Simplex 01/01/2013 - "JTS-653 reduced chronic pain at 0.3 mg/kg in herpes simplex virus-1-inoculated mice that has been reported as NSAID-refractory pain. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Freund's Adjuvant
3.	Formaldehyde (Formol)
4.	Carrageenan
5.	Capsaicin (Zostrix)
6.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)

Related Therapies and Procedures

1.	Ligation