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(R)- N- (4- (4- methoxyphenyl)thiazol- 2- yl)- 1- tosylpiperidine- 2- carboxamide

structure in first source

Also Known As:

ML277

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cui, Jianmin: 1 article (01/2019)
2.	Gao, Yuan: 1 article (01/2019)
3.	Hou, Panpan: 1 article (01/2019)
4.	Shi, Jingyi: 1 article (01/2019)
5.	White, Kelli McFarland: 1 article (01/2019)

Related Diseases

1.	Cardiac Arrhythmias (Arrythmia) 04/11/2023 - "ML277: (1) temporarily prevented repolarization prolongation induced by dofetilide (QTc: 538 ± 65 ms at induction vs. 393 ± 18 ms at prevention, p < 0.05), (2) delayed the occurrence of the first arrhythmic event upon dofetilide (from 129 ± 28 s to 180 ± 51 s, p < 0.05), and (3) decreased the arrhythmic outcome with a significant reduction in the number of TdP arrhythmias, TdP score, arrhythmia score and total arrhythmic events (from 669 ± 132 to 401 ± 228, p < 0.05). " 04/11/2023 - "TdP arrhythmia sensitivity was tested in anesthetized mongrel dogs (n = 7) with CAVB in series: (1) induction experiment at 4 ± 2 weeks CAVB: TdP arrhythmias were induced with our standardized protocol using dofetilide (0.025 mg/kg), and (2) prevention experiment at 10 ± 2 weeks CAVB: the antiarrhythmic effect of ML277 (0.6-1.0 mg/kg) was tested by infusion for 5 min preceding dofetilide. "
2.	Pain (Aches) 01/01/2023 - "In the present study, we assess the effects on sensory neuron excitability of three Kv7 modulators-retigabine (Kv7.2 thru Kv7.5 activator), ICA-110381 (Kv7.2/Kv7.3 specific activator), and as a comparator ML277 (Kv7.1 specific activator)-in a "human-pain-in-a-dish" model (human iPSC-derived sensory neurons, iPSC-SN). "
3.	Long QT Syndrome 01/01/2019 - "ML277 provides insights and a tool to investigate the gating mechanism of KCNQ1 channels, and our study reveals a new strategy for treating long QT syndrome by specifically enhancing the AO state of native IKs currents."
4.	Atrioventricular Block 04/11/2023 - "We examined the antiarrhythmic effect of IKs channel activator ML277 in the chronic atrioventricular block (CAVB) dog model. "
5.	Ischemia 05/01/2023 - "Here, we show that the slowly activating voltage-gated potassium current (IKs) potentiator ML277 imparts cardioprotection against ischemia in cellular and whole-heart models by modulating the action potential duration. "

Related Drugs and Biologics

1.	dofetilide (Tikosyn)
2.	4- chloro- N- (6- chloropyridin- 3- yl)benzamide
3.	ezogabine (retigabine)
4.	Potassium
5.	Dihydrotachysterol (AT 10)

Related Therapies and Procedures

1.	Ligation