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4- amino- 8- (2- fluoro- 6- methoxy- phenyl)- N- propylcinnoline- 3- carboxamide

a GABA(A) alpha2,3 receptor modulator; structure in first source

Also Known As:

AZD7325

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - 4-amino-8-(2-fluoro-6-methoxy-phenyl)-N-propylcinnoline-3-carboxamide: 2

Experts

1.	Contractor, Anis: 1 article (01/2019)
2.	George, Alfred L: 1 article (01/2019)
3.	Hawkins, Nicole A: 1 article (01/2019)
4.	Kearney, Jennifer A: 1 article (01/2019)
5.	Nomura, Toshihiro: 1 article (01/2019)
6.	Artelsmair, Markus: 1 article (01/2018)
7.	Chapdelaine, Marc: 1 article (01/2018)
8.	Christoph, Greg: 1 article (01/2018)
9.	Davis, Patty: 1 article (01/2018)
10.	Dembofsky, Bruce T: 1 article (01/2018)

Related Diseases

1.	Seizures (Absence Seizure) 01/01/2019 - "Consistent with this, treatment of Scn1a+/- mice with AZD7325 elevated the temperature threshold for hyperthermia-induced seizures without apparent sedative effects. "
2.	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/01/2019 - "The effect of AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain, which have been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/- ), and in which the α2 GABAA receptor subunits are expressed at higher levels relative to in the seizure prone C57BL/6J background strain. "
3.	Anxiety Disorders (Anxiety Disorder) 01/01/2018 - "AZD7325 [4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide] is a selective GABAAα2,3 receptor modulator intended for the treatment of anxiety disorders through oral administration. "

Related Drugs and Biologics

1.	Hypnotics and Sedatives (Sedatives)

Related Therapies and Procedures

1.	Induced Hyperthermia (Thermotherapy)
2.	Oral Administration