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2'- deoxy- 5- fluorouridylyl- (3'- 5')- 3'- C- ethynylcytidine

has antineoplastic activity; structure in first source

Also Known As:

5-FdU(3'-5')ECyd

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Oligonucleotides: 5145
      - 2'-deoxy-5-fluorouridylyl-(3'-5')-3'-C-ethynylcytidine: 1

Experts

1.	Berger, Alexander: 1 article (11/2012)
2.	Busch, Christian: 1 article (11/2012)
3.	Garbe, Claus: 1 article (11/2012)
4.	Ikenberg, Kristian: 1 article (11/2012)
5.	Meier, Friedegund: 1 article (11/2012)
6.	Niessner, Heike: 1 article (11/2012)
7.	Schott, Sarah: 1 article (11/2012)
8.	Sinnberg, Tobias: 1 article (11/2012)
9.	Venturelli, Sascha: 1 article (11/2012)
10.	Villanueva, Jessie: 1 article (11/2012)

Related Diseases

1.

Melanoma (Melanoma, Malignant)

11/01/2012 - "In vivo the duplex drug 5-FdU(3'-5')ECyd was efficacious in the murine LOX IMVI melanoma xenograph model on administration of 11.2 mg/kg/injection every fourth day. "
11/01/2012 - "In vitro (real-time)-proliferation assays demonstrated that 5-FdU(3'-5')ECyd and ECyd-lipid-5-FdU had a high cytotoxic efficacy causing 75% melanoma cell death at concentrations in the nanomolar and micromolar range. "

Related Drugs and Biologics

1.	3'- C- ethynylcytidinylyl- (5'- 1- O)- 2- O- octadecyl- sn- glycerylyl- (3- O- 5')- 2'- deoxy- 5- fluorouridine