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4- (2,3- dihydro- 1,4- benzodioxin- 6- yl)- 2,4- dihydro- 5- ((5- nitro- 2- thiazolyl)thio)- 3H- 1,2,4- triazol- 3- one

structure in first source

Also Known As:

BI-78D3

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-((5-nitro-2-thiazolyl)thio)-3H-1,2,4-triazol-3-one: 3
  - Dioxanes
    - 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-((5-nitro-2-thiazolyl)thio)-3H-1,2,4-triazol-3-one: 3
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-((5-nitro-2-thiazolyl)thio)-3H-1,2,4-triazol-3-one: 3

Experts

1.	Anslyn, Eric V: 1 article (11/2019)
2.	Cano, Micael: 1 article (11/2019)
3.	Dalby, Kevin N: 1 article (11/2019)
4.	Ebelt, Nancy D: 1 article (11/2019)
5.	Edupuganti, Ramakrishna: 1 article (11/2019)
6.	Ghose, Ranajeet: 1 article (11/2019)
7.	Harger, Matthew: 1 article (11/2019)
8.	Johnson, William H: 1 article (11/2019)
9.	Kaoud, Tamer S: 1 article (11/2019)
10.	Park, Jihyun: 1 article (11/2019)

Related Diseases

1.	Insulin Resistance 10/28/2008 - "In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes. "
2.	Type 2 Diabetes Mellitus (MODY) 10/28/2008 - "In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes. "
3.	Melanoma (Melanoma, Malignant) 11/19/2019 - "BI-78D3 promotes apoptosis in BRAF inhibitor-naive and resistant melanoma cells containing a BRAF V600E mutation. "
4.	Inflammation (Inflammations) 01/01/2018 - "BI-78D3, a JNK inhibitor, abrogated CS-induced neutrophilic inflammation in vivo in an air pouch model. "