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MI-192

histone deacetylase 2 and 3 inhibitor; structure in first source

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Demyanenko, S V: 1 article (01/2020)
2.	Nikul, V V: 1 article (01/2020)
3.	Uzdensky, A B: 1 article (01/2020)
4.	Brüning-Richardson, Anke: 1 article (01/2019)
5.	Harmer, Jane: 1 article (01/2019)
6.	Struve, Nina: 1 article (01/2019)
7.	Durham, Benjamin S: 1 article (10/2017)
8.	Grigg, Ronald: 1 article (10/2017)
9.	Wood, Ian C: 1 article (10/2017)

Related Diseases

1.	Necrosis 10/01/2017 - "In our study, we have identified that selective HDAC inhibition with inhibitors apicidin, MS-275 or MI-192, or specific knockdown of HDAC1 or 2 using siRNA, suppresses the expression of cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in BV-2 murine microglia activated with lipopolysaccharide (LPS). "
2.	Stroke (Strokes) 01/01/2020 - "Application of MI-192, an inhibitor of histone deacetylases HDAC2 and HDAC3, demonstrated the neuroprotective activity in the mouse brain subjected to photothrombotic stroke. "
3.	Glioma (Gliomas) 01/01/2019 - "The methodology described here, combining spheroid invasion assays with high-resolution image capture and data analysis by confocal laser scanning microscopy (CLSM), enabled detailed characterization of the effects of the potential anti-migratory inhibitor MI-192 on glioma cells. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Cytokines
3.	Interleukin-6 (Interleukin 6)
4.	Lipopolysaccharides
5.	entinostat (MS 275)
6.	apicidin
7.	Histone Deacetylases (Histone Deacetylase)

Related Therapies and Procedures

1.	Lasers (Laser)