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3- ((2,4- dichlorobenzyl)thio)- 1,6- dimethyl- 5,6- dihydro- 1H- pyridazino(4,5- e)(1,3,4)thiadiazin- 5- one

a T cell death-associated gene 8 agonist

Also Known As:

BTB09089

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridazines: 11
    - 3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one: 2
  - Thiazines: 3
    - Thiadiazines: 4
      - 3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazines: 3
    - Thiadiazines: 4
      - 3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one: 2

Experts

1.	Hang, L H: 1 article (01/2017)
2.	Hu, X L: 1 article (01/2017)
3.	Luo, H: 1 article (01/2017)
4.	Ma, X D: 1 article (01/2017)
5.	Shao, D H: 1 article (01/2017)
6.	Shu, W W: 1 article (01/2017)
7.	Fujita, Yoshifumi: 1 article (05/2012)
8.	Komai, Tomoaki: 1 article (05/2012)
9.	Kuwabara, Harumi: 1 article (05/2012)
10.	Nagasaki, Miyuki: 1 article (05/2012)

Related Diseases

1.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2017 - "Further evaluations were performed to increase TDAG8 expression 6h prior to middle cerebral artery occlusion (MCAO) by injecting a specific agonist, BTB09089, into the lateral ventricle to increase TDAG8 expression. "
2.	Ovarian Neoplasms (Ovarian Cancer) 05/15/2012 - "BTB09089 did not act on other proton sensing G-protein-coupled receptors such as G-protein-coupled receptor 4 (GPR4) nor ovarian cancer G-protein-coupled receptor 1 (OGR1). "
3.	Infarction (Infarctions) 01/01/2017 - "Pretreatment with BTB09089 up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72h after MCAO. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
3.	Protons (Proton)