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N- (4- cyanophenylmethyl)- 4- (2- diphenyl)- 1- piperazinehexanamide

a 5-HT(7) receptor agonist

Also Known As:

LP-211

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide: 7

Experts

1.	Lacivita, Enza: 4 articles (10/2017 - 01/2014)
2.	Leopoldo, Marcello: 4 articles (10/2017 - 01/2014)
3.	Laviola, Giovanni: 2 articles (07/2017 - 01/2014)
4.	Barati, Fardin: 2 articles (01/2016 - 09/2015)
5.	Dehpour, Ahmad Reza: 2 articles (01/2016 - 09/2015)
6.	Fakhraei, Nahid: 2 articles (01/2016 - 09/2015)
7.	Javanbakht, Javad: 2 articles (01/2016 - 09/2015)
8.	Mohammadi, Fatemeh: 2 articles (01/2016 - 09/2015)
9.	Norouzi-Javidan, Abbas: 2 articles (01/2016 - 09/2015)
10.	Chu, Shuaishuai: 1 article (01/2021)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 07/15/2017 - "The present study extends previous findings by demonstrating that LP-211 treatment (0.25 mg/kg, once per day for 7 days) rescues mitochondrial respiratory chain impairment, oxidative phosphorylation deficiency and the reduced energy status in the brain of heterozygous female mice from two highly validated mouse models of RTT (MeCP2-308 and MeCP2-Bird mice). " 07/15/2017 - "These results provide the first evidence that RTT brain mitochondrial dysfunction can be rescued targeting the brain 5-HT7R and add compelling preclinical evidence of the potential therapeutic value of LP-211 as a pharmacological approach for this devastating neurodevelopmental disorder."
2.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2016 - "Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats." 09/14/2015 - "The observed controversy that N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (LP-211), a selective serotonin (5-HT7) receptor agonist, may either modify or exacerbate imbalances in serum electrolyte concentrations and renal tissue of spinal cord trauma cases has not been reported yet. "
3.	Neurodevelopmental Disorders 07/15/2017 - "These results provide the first evidence that RTT brain mitochondrial dysfunction can be rescued targeting the brain 5-HT7R and add compelling preclinical evidence of the potential therapeutic value of LP-211 as a pharmacological approach for this devastating neurodevelopmental disorder."
4.	Chronobiology Disorders (Circadian Rhythm Disorder) 01/01/2021 - "Our results show the appropriate dose of SB-269970 significantly alleviated the circadian rhythm disorder induced by isoflurane anesthesia, while LP-211 significantly aggravated it after anesthesia, which is different from the phase shift that can be caused by the administration of LP-211 before anesthesia. "
5.	Sleep Wake Disorders 01/01/2014 - "Subchronic LP-211 in rats and mice appears to be a suitable tool for studying the role of 5-HT7-R in sleep disorders, emotional/motivational regulations, attentive processes and executive functions."

Related Drugs and Biologics

1.	serotonin 7 receptor
2.	Serotonin (5 Hydroxytryptamine)
3.	Cyclic Nucleotides
4.	Isoflurane
5.	Electrolytes
6.	SB 269970

Related Therapies and Procedures

1.	Therapeutics
2.	Anesthesia