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lipoxin A4 methyl ester

attenuates morphine antinociceptive tolerance

Also Known As:

LXA4 methyl ester; LXA4ME

Networked: 6 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Lipoxins: 529
        lipoxin A4 methyl ester: 6

Experts

1.	Gao, Jin: 1 article (12/2021)
2.	Li, Long-Cheng: 1 article (12/2021)
3.	Wang, Xue-Song: 1 article (12/2021)
4.	Zhang, Xue: 1 article (12/2021)
5.	Cui, Jianzhong: 1 article (03/2019)
6.	Cui, Ying: 1 article (03/2019)
7.	Gao, Junling: 1 article (03/2019)
8.	Song, Yaqi: 1 article (03/2019)
9.	Wang, Kaijie: 1 article (03/2019)
10.	Yang, Ying: 1 article (03/2019)

Related Diseases

1.	Stroke (Strokes) 09/01/2015 - "Lipoxin A4 methyl ester (LXA4 ME) is an inflammation inhibitor that exhibits potent protective effects in experimental stroke models. "
2.	Pheochromocytoma 12/01/2021 - "In this work, we explored the protective effects of lipoxin A4 methyl ester (LXA4 ME) against ketamine-induced neurotoxicity and the underlying protective mechanism in pheochromocytoma (PC12) cells. "
3.	Inflammation (Inflammations) 09/01/2015 - "Lipoxin A4 methyl ester (LXA4 ME) is an inflammation inhibitor that exhibits potent protective effects in experimental stroke models. "
4.	Hyperalgesia 04/19/2012 - "However, LXA4ME treatment significantly attenuated the development of hyperalgesia and the expression of spinal antinociceptive tolerance to intrathecal morphine in both mechanical and thermal test. " 04/19/2012 - "The present study investigated the effect of 5 (S), 6 (R)-lipoxin A4 methyl ester (LXA4ME), a stable synthetic analog of lipoxin A4, on the expression of antinociceptive tolerance and withdrawal-induced hyperalgesia in chronic morphine-treated rats. "
5.	Brain Injuries (Brain Injury) 06/01/2023 - "Lipoxin A4 methyl ester (LXA4 ME) is relatively stable lipoxin analog, which serves an important role in protecting against early brain injury. " 03/11/2019 - "Lipoxin A4 Methyl Ester Reduces Early Brain Injury by Inhibition of the Nuclear Factor Kappa B (NF-κB)-Dependent Matrix Metallopeptidase 9 (MMP-9) Pathway in a Rat Model of Intracerebral Hemorrhage."

Related Drugs and Biologics

1.	lipoxin A4
2.	Ketamine
3.	lipoxin A4 methyl ester
4.	Morphine (MS Contin)
5.	S 6 (S-6)
6.	Metalloproteases (Metalloproteinases)
7.	Lipoxins
8.	Neuroprotective Agents
9.	NF-kappa B (NF-kB)