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5- methyl- N- (2- (pyridin- 3- ylmethyl)- 1- azabicyclo(2.2.2)oct- 3- yl)thiophene- 2- carboxamide

structure in first source

Also Known As:

TC-7020

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 5-methyl-N-(2-(pyridin-3-ylmethyl)-1-azabicyclo(2.2.2)oct-3-yl)thiophene-2-carboxamide: 2
- Bridged-Ring Heterocyclic Compounds
  - Quinuclidines: 20
    - 5-methyl-N-(2-(pyridin-3-ylmethyl)-1-azabicyclo(2.2.2)oct-3-yl)thiophene-2-carboxamide: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - 5-methyl-N-(2-(pyridin-3-ylmethyl)-1-azabicyclo(2.2.2)oct-3-yl)thiophene-2-carboxamide: 2

Experts

1.	Green, Heather: 1 article (12/2012)
2.	James, John W: 1 article (12/2012)
3.	Jordan, Kristen G: 1 article (12/2012)
4.	Letchworth, Sharon R: 1 article (12/2012)
5.	Loram, Lisa C: 1 article (12/2012)
6.	Maier, Steven F: 1 article (12/2012)
7.	Mazarov, Anatoly: 1 article (12/2012)
8.	Pritchard, Robert C: 1 article (12/2012)
9.	Speake, Jason D: 1 article (12/2012)
10.	Strand, Keith A: 1 article (12/2012)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 12/01/2012 - "These studies demonstrated that TC-7020, an alpha7 nicotinic acetylcholine receptor agonist with partial blood-brain barrier permeability, reversed neuropathic pain in rats, likely via attenuation of inflammation in the DRG and/or the site of sciatic injury."
2.	Inflammation (Inflammations) 12/01/2012 - "These studies demonstrated that TC-7020, an alpha7 nicotinic acetylcholine receptor agonist with partial blood-brain barrier permeability, reversed neuropathic pain in rats, likely via attenuation of inflammation in the DRG and/or the site of sciatic injury."
3.	Weight Gain 01/01/2010 - "Oral administration of TC-7020 reduced weight gain and food intake, reduced elevated glucose and glycated hemoglobin levels, and lowered elevated plasma levels of triglycerides and the proinflammatory cytokine tumor necrosis factor-alpha. "
4.	Hyperalgesia 12/01/2012 - "TC-7020 (1, 3, and 10 mg/kg/d; s.c.) significantly attenuated CCI-induced allodynia, which lasted through 2 weeks of test compound administration. "

Related Drugs and Biologics

1.	alpha7 Nicotinic Acetylcholine Receptor
2.	Cytokines
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Triglycerides (Triacylglycerol)
5.	Glycated Hemoglobin (Glycosylated Hemoglobin)
6.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Oral Administration