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7- chloro- 3- methyl- 2- (4- (4- (trifluoromethoxy)benzyl)phenyl)quinolin- 4(1H)- one

an antimalarial; structure in first source

Also Known As:

CK-2-68

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one: 2

Experts

1.	Amewu, Richard: 1 article (03/2012)
2.	Berger, Olivier: 1 article (03/2012)
3.	Berry, Neil G: 1 article (03/2012)
4.	Biagini, Giancarlo A: 1 article (03/2012)
5.	Charoensutthivarakul, Sitthivut: 1 article (03/2012)
6.	Fisher, Nicholas E: 1 article (03/2012)
7.	Gibbons, Peter: 1 article (03/2012)
8.	Hill, Alasdair: 1 article (03/2012)
9.	Hong, W David: 1 article (03/2012)
10.	Leung, Suet C: 1 article (03/2012)

Related Diseases

1.

01/01/2023 - "The compound CK-2-68 was developed to specifically target the alternate NADH dehydrogenase of the malaria parasite respiratory chain, but the true target for its antimalarial activity has been controversial. "
03/08/2012 - "Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of CK-2-68, a molecule suitable for further development. "

Related Drugs and Biologics

1.	Electron Transport Complex I (NADH-CoQ Reductase)
2.	NADH Dehydrogenase
3.	Enzymes
4.	Antimalarials (Antimalarial Agents)