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UPEI-100

has neuroprotective activity; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Connell, Barry J: 2 articles (04/2015 - 04/2012)
2.	Saleh, Tarek M: 2 articles (04/2015 - 04/2012)
3.	Abd-El-Aziz, Alaa S: 1 article (04/2015)
4.	Kucukkaya, Inan: 1 article (04/2015)
5.	Khan, Bobby V: 1 article (04/2012)
6.	Rajagopal, Desikan: 1 article (04/2012)
7.	Saleh, Monique C: 1 article (04/2012)

Related Diseases

1.	Stroke (Strokes) 04/01/2012 - "Using the optimal dose, we then injected UPEI-100 during the stroke or at several time points during reperfusion, and significant neuroprotection was observed when UPEI-100 was administered up to 90 min following the start of reperfusion (P < 0.05). " 04/01/2012 - "Preadministration of UPEI-100 dose-dependently decreased infarct volume in the I/R model (P < 0.05), but not in the middle cerebral artery occlusion model of stroke. " 04/01/2012 - "Therefore, the present investigation was designed to determine whether a co-drug consisting of lipoic acid and apocynin functional groups bound by a covalent bond, named UPEI-100, is capable of similar efficacy using a rodent model of stroke. "
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/01/2012 - "Preadministration of UPEI-100 dose-dependently decreased infarct volume in the I/R model (P < 0.05), but not in the middle cerebral artery occlusion model of stroke. "
3.	Reperfusion Injury 04/21/2015 - "In an animal model of ischemia-reperfusion injury (tMCAO), UPEI-100 was shown to produce equivalent neuroprotection compared to each parent compound, but at a 100-fold lower dose. "
4.	Ischemia 04/01/2012 - "UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion."
5.	Infarction (Infarctions) 04/01/2012 - "A time course for this neuroprotective effect showed that UPEI-100 resulted in a decrease in infarct volume following 2 h of reperfusion compared with vehicle. " 04/01/2012 - "Preadministration of UPEI-100 dose-dependently decreased infarct volume in the I/R model (P < 0.05), but not in the middle cerebral artery occlusion model of stroke. "

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	Thioctic Acid (Lipoic Acid)
3.	acetovanillone (apocynin)