2,3,7,7a- tetrahydro- 3- hydroxy- 7- methyl- 2- (prop- 1- en- 1- yl)- 5H- furo(3,4- b)pyran- 5- one

theissenolactones B and C are the (2R,3R,7R,7aR)- and (2R,3R,7S,7aR)-isomers, respectively; has antineoplastic activity; isolated from Theissenia cinerea; structure in first source

Also Known As:

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chang, Hung-Ming: 2 articles (03/2019 - 01/2018)
2.	Cheng, Yu-Wen: 2 articles (03/2019 - 01/2018)
3.	Chiou, George C Y: 2 articles (03/2019 - 01/2018)
4.	Ho, Jau-Der: 2 articles (03/2019 - 01/2018)
5.	Hsiao, George: 2 articles (03/2019 - 01/2018)
6.	Lee, Tzong-Huei: 2 articles (03/2019 - 01/2018)
7.	Lin, Fan-Li: 2 articles (03/2019 - 01/2018)
8.	Kuo, Yu-Cheng: 1 article (03/2019)
9.	Yu, Min: 1 article (03/2019)
10.	Yen, Jing-Lun: 1 article (01/2018)

Related Diseases

1.	Uveitis 03/15/2019 - "We previously reported that fungal derivative theissenolactone C (LC53) could exert ocular protective effects by suppressing neuroinflammation in experimental uveitis. " 01/01/2018 - "Theissenolactone C Exhibited Ocular Protection of Endotoxin-Induced Uveitis by Attenuating Ocular Inflammatory Responses and Glial Activation." 01/01/2018 - "The aim of this study was to investigate the effects of a natural component, theissenolactone C (LC53), on the ocular inflammation of experimental endotoxin-induced uveitis (EIU) and its related mechanisms in microglia. "
2.	Neuroinflammatory Diseases 03/15/2019 - "We previously reported that fungal derivative theissenolactone C (LC53) could exert ocular protective effects by suppressing neuroinflammation in experimental uveitis. "
3.	Retinal Degeneration 02/01/2023 - "The present study investigates the effects and mechanisms of the natural compound theissenolactone B (LB53), isolated from Theissenia cinerea, on the effects of RPE dysregulation and microglia hyperactivation and its retinal protective ability in a sodium iodate (NaIO3)-induced retinal degeneration model of AMD. "
4.	Inflammation (Inflammations) 01/01/2018 - "The aim of this study was to investigate the effects of a natural component, theissenolactone C (LC53), on the ocular inflammation of experimental endotoxin-induced uveitis (EIU) and its related mechanisms in microglia. "
5.	Glaucoma 03/15/2019 - "The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition."

Related Drugs and Biologics

1.	Retinaldehyde (Retinal)
2.	Endotoxins
3.	sodium iodate