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8- (4- methylpiperazin- 1- yl)- 3- phenylsulfonylquinoline

a 5-HT6 receptor antagonist; structure in first source

Also Known As:

(3H)8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline; (3H)Lu AE60157; Lu AE60157

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - 8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline: 1

Experts

1.	Arnt, Jorn: 1 article (09/2010)
2.	Bang-Andersen, Benny: 1 article (09/2010)
3.	Bymaster, Franklin P: 1 article (09/2010)
4.	Cohen, Michael P: 1 article (09/2010)
5.	DeLapp, Neil W: 1 article (09/2010)
6.	Giethlen, Bruno: 1 article (09/2010)
7.	Grayson, Ben: 1 article (09/2010)
8.	Kreilgaard, Mads: 1 article (09/2010)
9.	McKinzie, David L: 1 article (09/2010)
10.	Neill, Joanna C: 1 article (09/2010)

Related Diseases

1.

Cognitive Dysfunction

09/01/2010 - "Orally administered Lu AE58054 potently inhibited striatal in-vivo binding of the 5-HT(6) antagonist radioligand [(3)H]Lu AE60157 ([(3)H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline), with an ED(50) of 2.7 mg/kg. Steady-state modelling of an acute pharmacokinetic/5-HT(6)R occupancy time-course experiment indicated a plasma EC(50) value of 20 ng/ml. Administration of Lu AE58054 in a dose range (5-20 mg/kg p.o.) leading to above 65% striatal 5-HT(6)R binding occupancy in vivo, reversed cognitive impairment in a rat novel object recognition task induced after subchronic treatment for 7 d with phencyclidine (PCP 2 mg/kg b.i.d., i.p. "

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