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NO-rofe
a rofecoxib derivative with antineoplastic activity; structure in first source
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Inorganic Chemicals: 9
Electrolytes: 16106
Ions: 7857
Anions: 3501
Nitrates: 6625
NO-rofe: 1
Nitrogen Compounds: 67
Nitric Acid: 155
Nitrates: 6625
NO-rofe: 1
Organic Chemicals: 133
Nitrates: 6625
NO-rofe: 1
Lactones: 1549
4-Butyrolactone: 81
NO-rofe: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Furans: 85
4-Butyrolactone: 81
NO-rofe: 1
Experts
1.
Bocca, Claudia
: 1 article (02/2012)
2.
Bozzo, Francesca
: 1 article (02/2012)
3.
Ievolella, Monica
: 1 article (02/2012)
4.
Miglietta, Antonella
: 1 article (02/2012)
Related Diseases
1.
Colonic Neoplasms (Colon Cancer)
02/01/2012 - "
NO-rofe exerted a significant antiproliferative activity on COX-2 positive HT-29 human colon cancer cells, being less effective on the COX-2 negative SW-480 human colon cancer cell line.
"
02/01/2012 - "
In this study, the antiproliferative activity of a novel dinitro-oxy-substituted analogue of rofecoxib (NO-rofe), potentially less cardiotoxic, has been investigated in vitro on human colon cancer cells and compared with the action of the parent drug.
"
Related Drugs and Biologics
1.
rofecoxib (Vioxx)