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6- (3- cyclopentyl- 2- (4- (trifluoromethyl)- 1H- imidazol- 1- yl)propanamido)nicotinic acid

An hepatoselective glucokinase activator.

Also Known As:

6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid; PF-04991532

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid: 2
  - Pyridines: 88
    - Nicotinic Acids: 13
      - 6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid: 2
- Heterocyclic Acids
  - Nicotinic Acids: 13
    - 6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid: 2

Experts

1.	Pfefferkorn, Jeffrey A: 2 articles (02/2015 - 01/2014)
2.	Atkinson, Karen: 1 article (02/2015)
3.	Bergman, Arthur: 1 article (02/2015)
4.	Di, Li: 1 article (02/2015)
5.	Gustavson, Stephanie M: 1 article (02/2015)
6.	Kalgutkar, Amit S: 1 article (02/2015)
7.	Kazierad, David: 1 article (02/2015)
8.	Litchfield, John: 1 article (02/2015)
9.	Sharma, Raman: 1 article (02/2015)
10.	Aiello, Robert J: 1 article (01/2014)

Related Diseases

1.	Hyperglycemia 01/01/2014 - "The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats."
2.	Type 2 Diabetes Mellitus (MODY) 02/01/2015 - "A previous report from our laboratory disclosed the identification of PF-04991532 [(S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid] as a hepatoselective glucokinase activator for the treatment of type 2 diabetes mellitus. "

Related Drugs and Biologics

1.	Glucokinase
2.	Niacin (Nicotinic Acid)
3.	S 6 (S-6)