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LCH-7749944

potent p21-activated kinase 4 inhibitor, structure in first source

Also Known As:

N2-(3-methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - LCH-7749944: 2

Experts

1.	Cao, L: 1 article (06/2014)
2.	Cheng, M: 1 article (06/2014)
3.	Guo, Q: 1 article (06/2014)
4.	Li, F: 1 article (06/2014)
5.	Li, X: 1 article (06/2014)
6.	Miao, Z: 1 article (06/2014)
7.	Su, N: 1 article (06/2014)
8.	Wang, G: 1 article (06/2014)
9.	Xu, H: 1 article (06/2014)
10.	Zhang, J: 1 article (06/2014)

Related Diseases

1.

Stomach Neoplasms (Stomach Cancer)

06/19/2014 - "Inhibiting PAK4, either by LCH-7749944 or RNA interference, resulted in the inhibition of Ser50 phosphorylation and a blockade to cell invasion, suggesting that PAK4-SCG10 signaling occurs in gastric cancer cell invasion. "
04/01/2012 - "In this paper we found that LCH-7749944, a novel and potent PAK4 inhibitor, effectively suppressed the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway. "
04/01/2012 - "LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells."
04/01/2012 - "In addition, LCH-7749944 significantly inhibited the migration and invasion of human gastric cancer cells in conjunction with concomitant blockage of PAK4/LIMK1/cofilin and PAK4/MEK-1/ERK1/2/MMP2 pathways. "

Related Drugs and Biologics

1.	p21-Activated Kinases
2.	Actin Depolymerizing Factors (Cofilins)
3.	Mitogen-Activated Protein Kinase Kinases (MEKs)
4.	Cyclin D1