Premature Ovarian Failure 5

aka POF5; associated with mutations in NOBOX

Also Known As:

Pof5

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Urogenital Diseases: 126
- Genital Diseases: 114
  - Female Genital Diseases: 393
    - Adnexal Diseases: 60
      - Ovarian Diseases: 665
        Primary Ovarian Insufficiency: 1562
        Premature Ovarian Failure 5: 3
- Female Urogenital Diseases and Pregnancy Complications
  - Female Urogenital Diseases
    - Female Genital Diseases: 393
      - Adnexal Diseases: 60
        Ovarian Diseases: 665
        Primary Ovarian Insufficiency: 1562
        Premature Ovarian Failure 5: 3
Endocrine System Diseases: 968
- Gonadal Disorders: 30
  - Ovarian Diseases: 665
    - Primary Ovarian Insufficiency: 1562
      - Premature Ovarian Failure 5: 3

Experts

1.	Ahmed, K A: 2 articles (01/2008 - 10/2007)
2.	Anish, D: 2 articles (01/2008 - 10/2007)
3.	Sastry, K V H: 2 articles (01/2008 - 10/2007)
4.	Saxena, M: 2 articles (01/2008 - 10/2007)
5.	Saxena, V K: 2 articles (01/2008 - 10/2007)
6.	Sundaresan, N R: 2 articles (01/2008 - 10/2007)
7.	Hrabia, Anna: 1 article (01/2018)
8.	Sechman, Andrzej: 1 article (01/2018)
9.	Socha, Joanna K: 1 article (01/2018)
10.	Kantaraja, C: 1 article (01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Premature Ovarian Failure 5:

1.	Messenger RNA (mRNA)IBA 10/01/2007 - "However, the level of iNOS mRNA was declined immediately after ovulation and thereafter upregulated again to reach a peak in POF3 with a subsequent reduction in POF5 to below the basal level. " 01/01/2018 - "The relative expression (RQ) of caspase-2, -3, -8 and -9 mRNA increased (P < 0.05) in POF5, while the activity of all examined caspases elevated gradually (approximately 80-150%) reaching the highest level in POF3, and then slowly decreased to the value noted in POF1 (P < 0.05 - P < 0.001). "
2.	Initiator CaspasesIBA 01/01/2008 - "During the regression of the POF, caspase-3 was activated during initial stages, whereas the initiator caspases were upregulated at the later stages (POF4 and POF5). "
3.	Caspase 3 (Caspase-3)IBA 01/01/2008 - "During the regression of the POF, caspase-3 was activated during initial stages, whereas the initiator caspases were upregulated at the later stages (POF4 and POF5). "
4.	Caspase 2IBA 01/01/2018 - "The relative expression (RQ) of caspase-2, -3, -8 and -9 mRNA increased (P < 0.05) in POF5, while the activity of all examined caspases elevated gradually (approximately 80-150%) reaching the highest level in POF3, and then slowly decreased to the value noted in POF1 (P < 0.05 - P < 0.001). "
5.	CaspasesIBA 01/01/2018 - "The relative expression (RQ) of caspase-2, -3, -8 and -9 mRNA increased (P < 0.05) in POF5, while the activity of all examined caspases elevated gradually (approximately 80-150%) reaching the highest level in POF3, and then slowly decreased to the value noted in POF1 (P < 0.05 - P < 0.001). "