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Fatal Infantile Lactic Acidosis

Also Known As:

Lactic Acidosis, Fatal Infantile

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10634
  - Acid-Base Imbalance: 257
    - Acidosis: 17451
      - Lactic Acidosis: 3935
        Fatal Infantile Lactic Acidosis: 5

Related Diseases

1.	Mitochondrial complex I deficiency

Experts

1.	Christensen, Ernst: 2 articles (02/2010 - 08/2007)
2.	Ostergaard, Elsebet: 2 articles (02/2010 - 08/2007)
3.	Boles, Richard G: 1 article (02/2011)
4.	Jackson, Hollie A: 1 article (02/2011)
5.	Randolph, Linda M: 1 article (02/2011)
6.	Sanchez-Lara, Pedro A: 1 article (02/2011)
7.	Shimada, Hiroyuki: 1 article (02/2011)
8.	Wang, Jing: 1 article (02/2011)
9.	Wong, Derek A: 1 article (02/2011)
10.	Wong, Lee-Jun: 1 article (02/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fatal Infantile Lactic Acidosis:

1.	Mitochondrial DNA (mtDNA)IBA 02/01/2011 - "In this report, we describe a patient with fatal infantile lactic acidosis associated with mutations in the SUCLG1 gene and mtDNA depletion. " 02/01/2011 - "Fatal infantile lactic acidosis and a novel homozygous mutation in the SUCLG1 gene: a mitochondrial DNA depletion disorder." 03/01/2006 - "Sporadic intragenic inversion of the mitochondrial DNA MTND1 gene causing fatal infantile lactic acidosis." 08/01/2007 - "Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion."
2.	Succinic Acid (Succinate)IBA 08/01/2007 - "Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion."
3.	EnzymesIBA 02/01/2010 - "Mutations in SUCLG1, encoding the alpha subunit of the enzyme, have been reported in only one family, where a homozygous 2 bp deletion was associated with fatal infantile lactic acidosis. "
4.	DNA (Deoxyribonucleic Acid)IBA 07/01/1999 - "Nuclear DNA origin of mitochondrial complex I deficiency in fatal infantile lactic acidosis evidenced by transnuclear complementation of cultured fibroblasts."
5.	Coenzyme A Ligases (Acid-Thiol Ligases)IBA 08/01/2007 - "Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion."