Actinic Prurigo

03/01/2020 - "Thalidomide: An option for the pediatric patient with actinic prurigo."
12/01/2004 - "Actinic prurigo patients were analyzed before and after thalidomide treatment. "
12/01/2004 - "Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo."
11/01/2001 - "Long-term thalidomide for actinic prurigo."
08/01/2001 - "A 31-year-old Australian woman who had suffered actinic prurigo for most of her life was treated with two courses of thalidomide (50-100 mg nocte) over consecutive summers. "

03/13/2017 - "We report the first case of actinic prurigo in a Scandinavian patient, responding favorably to systemic treatment with cyclosporine A."
03/13/2017 - "Actinic Prurigo in Scandinavian Adolescent Successfully Treated with Cyclosporine A."
11/01/2006 - "[Topical cyclosporine in the treatment of ocular actinic prurigo]."
03/01/2002 - "Actinic prurigo patients were treated with cyclosporin A (CsA), and a final skin biopsy was taken after 6 months of treatment. "
03/01/2002 - "Lymphocyte subtypes and adhesion molecules in actinic prurigo: observations with cyclosporin A."

12/01/2000 - "Cyclosporine eyedrops may be an effective treatment for the conjunctival manifestations of actinic prurigo."
03/01/2007 - "Cyclosporine eye drops might also have utility in treating eye pathology of ocular rosacea, atopic keratoconjunctivitis, graft versus host disease, herpes keratitis, chronic sarcoidosis of the conjunctiva, conjunctival manifestations of actinic prurigo, keratitis of keratitis-ichthyosis deafness (KID) syndrome, and lichen planus-related kerato-conjunctivitis. "

11/01/2020 - "Clearance of pediatric actinic prurigo with dupilumab."
01/01/2021 - "Dupilumab for the Treatment of Actinic Prurigo."
11/01/2020 - "We present a pediatric patient with severe, recalcitrant actinic prurigo who achieved rapid and sustained clearance with dupilumab."

01/01/2016 - "Studies have reported the association of human leukocyte antigen (HLA) genes with susceptibility to develop actinic prurigo (AP) in Caucasians, but there were no studies in Asian populations, including the Chinese. "
11/01/2001 - "A recent positive finding of human leukocyte antigen (HLA) DR4 with the rare DRB1*0407 subtype confirmed a diagnosis of actinic prurigo. "
08/01/2001 - "Actinic prurigo is an uncommon and usually persistent idiopathic photodermatosis with typical human leukocyte antigen (HLA) associations (HLA-DR4, particularly subtypes DRB1*0407 and DRB1*0401). "
09/01/2000 - "It also suggests that polymorphic light eruption and actinic prurigo share a common genetic background, supporting the view that actinic prurigo may represent a human leukocyte antigen-restricted subset of polymorphic light eruption."
02/01/1996 - "Human leukocyte antigen (HLA) associations have been reported in Amerindian patients with actinic prurigo. "

04/01/2006 - "The objective of this study was to establish whether there was an association of actinic prurigo with HLA DR in a Colombian population. "
03/01/2002 - "In actinic prurigo patients, there was a significant increase in the number of CD3, CD4, CD8, CD45RA, CD45RO, and CD45RB lymphocytes and Langerhans cells, as well as in the level of human leukocyte antigen-DR (HLA-DR) expression and cell adhesion molecules lymphocyte functional antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and endothelial leukocyte adhesion molecule-1 (ELAM-1). "

03/01/2006 - "Immune responses to isolated human skin antigens in actinic prurigo."
02/01/1996 - "To determine if similar associations are present in the British Caucasoid population with actinic prurigo, 26 patients underwent serological typing for HLC Class I and II antigens. "
04/01/1991 - "We previously found that actinic prurigo, an idiopathic photodermatosis particularly associated with Amerindians, has a positive association with antigens A24 and Cw4 and a negative association with A3. "
06/01/1990 - "We present the human lymphocyte antigen (HLA) findings of 43 Chimilas with the disease and of 62 control subjects and show an association of actinic prurigo with the Cw4 antigen."
06/01/1990 - "Thirty-two actinic prurigo patients of Cree ancestry underwent human lymphocyte antigen (HLA) typing and were compared with 32 control subjects of Cree ancestry. "

02/01/1997 - "Actinic prurigo and HLA-DR4."
02/01/1996 - "DRB1*0407 is rare in European Caucasoids without actinic prurigo, and HLA-DR4 may have an important role in determining expression of this disease."
02/01/1996 - "HLA-DR4 may determine expression of actinic prurigo in British patients."
06/01/1997 - "Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo."

01/01/2021 - "Human leukocyte antigen (HLA) class II typing was positive for HLA-DRB1*0407, thus confirming the diagnosis of actinic prurigo (AP)."
04/01/2006 - "Human leukocyte antigen (HLA) DRB1*0407 had been associated with actinic prurigo in different populations. "

01/01/1998 - "The involvement of keratinocytes in the pathogenesis of actinic prurigo is suggested by the expression of ICAM-1 on these cells."
03/01/2002 - "In actinic prurigo patients, there was a significant increase in the number of CD3, CD4, CD8, CD45RA, CD45RO, and CD45RB lymphocytes and Langerhans cells, as well as in the level of human leukocyte antigen-DR (HLA-DR) expression and cell adhesion molecules lymphocyte functional antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and endothelial leukocyte adhesion molecule-1 (ELAM-1). "
01/01/1998 - "An increased expression of LFA-1, LFA-2, ICAM-3, VLA-4, and activated b1 integrins was observed in the cell infiltrate of actinic prurigo lesions and an up-regulated expression of ICAM-1 was detected in keratinocytes from these specimens. "

08/01/1981 - "Actinic prurigo is a chronic disease that often is refractory to therapy."
11/01/2006 - "Successful thalidomide therapy for actinic prurigo in a European woman."
01/01/2002 - "Actinic prurigo is managed again by restriction of UVR and the use of high SPF sunscreens; PUVA or broadband UVB therapy, or low doses of thalidomide may be necessary. "

07/01/2010 - "Some of the innovative but off-label uses of thalidomide include aphthous stomatitis, Behçet's disease, lupus erythematosus, prurigo nodularis, sarcoidosis, actinic prurigo, graft-versus-host disease, Langerhans cell histiocytosis, erythema multiforme, lichen planus, Kaposi sarcoma, Jessner lymphocytic infiltrate, uremic pruritus, pyoderma gangrenosum, scleroderma, scleromyxedema, and necrobiosis lipoidica. "

06/01/1995 - "Twenty patients with photodermatoses [actinic prurigo (n = 6), hydroa vacciniforme (n = 4), idiopathic solar urticaria (n = 1), amiodarone-induced photosensitivity (n = 1) and a range of cutaneous porphyrias (n = 8)] were treated with a 'hardening' course of narrow-band ultraviolet B (TL-01) phototherapy in springtime. "

04/01/1983 - "Thalidomide is an effective drug in the treatment of actinic prurigo but it must be used with adequate contraception in women of child-bearing age."