Cerebral Cavernous Malformations 3

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Neurologic Manifestations: 7102
  - Neurobehavioral Manifestations: 1586
    - Intellectual Disability: 8035
      - Cerebral Cavernous Malformations 3: 4
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7102
    - Neurobehavioral Manifestations: 1586
      - Intellectual Disability: 8035
        Cerebral Cavernous Malformations 3: 4
Behavior and Behavior Mechanisms
- Neurobehavioral Manifestations: 1586
  - Intellectual Disability: 8035
    - Cerebral Cavernous Malformations 3: 4
Mental Disorders: 24177
- Neurodevelopmental Disorders: 3095
  - Intellectual Disability: 8035
    - Cerebral Cavernous Malformations 3: 4
Musculoskeletal Diseases: 719
- Musculoskeletal Abnormalities: 43
  - Craniofacial Abnormalities: 203
    - Maxillofacial Abnormalities: 10
      - Jaw Abnormalities: 10
        Micrognathism: 338
        Cerebral Cavernous Malformations 3: 4
- Jaw Diseases: 15
  - Jaw Abnormalities: 10
    - Micrognathism: 338
      - Cerebral Cavernous Malformations 3: 4
Stomatognathic Diseases: 705
- Jaw Diseases: 15
  - Jaw Abnormalities: 10
    - Micrognathism: 338
      - Cerebral Cavernous Malformations 3: 4
- Stomatognathic System Abnormalities
  - Maxillofacial Abnormalities: 10
    - Jaw Abnormalities: 10
      - Micrognathism: 338
        Cerebral Cavernous Malformations 3: 4
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Musculoskeletal Abnormalities: 43
    - Craniofacial Abnormalities: 203
      - Maxillofacial Abnormalities: 10
        Jaw Abnormalities: 10
        Micrognathism: 338
        Cerebral Cavernous Malformations 3: 4
  - Stomatognathic System Abnormalities
    - Maxillofacial Abnormalities: 10
      - Jaw Abnormalities: 10
        Micrognathism: 338
        Cerebral Cavernous Malformations 3: 4
Musculoskeletal System
- Skeleton
  - Bone and Bones
    - Rib Cage
      - Ribs
        Cerebral Cavernous Malformations 3: 4

Related Diseases

1.	Central Nervous System Cavernous Hemangioma
2.	Cerebral Cavernous Malformations 2

Experts

1.	Boggon, Titus J: 2 articles (01/2020 - 05/2014)
2.	Fisher, Oriana S: 2 articles (01/2020 - 05/2014)
3.	Chen, Jingli: 1 article (10/2020)
4.	He, Yun: 1 article (10/2020)
5.	Li, Jiong: 1 article (10/2020)
6.	Luan, Xiaoyi: 1 article (10/2020)
7.	Min, Wang: 1 article (10/2020)
8.	Sun, Yi: 1 article (10/2020)
9.	Zhang, Haifeng: 1 article (10/2020)
10.	Zhao, Zhiqiang: 1 article (10/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebral Cavernous Malformations 3:

1.	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/01/2020 - "In this study, we aimed to explore the role of nitric oxide (NO) in regulating angiogenesis in cerebral cavernous malformations 3 gene (CCM3)-deficient mice exposed to lead during vascular development; further, we aimed to identify and study the potential mechanism involved as well. "
2.	Proteins (Proteins, Gene)FDA Link 01/01/2020 - "Cerebral cavernous malformations (CCM) are dysplasias that primarily occur in the neurovasculature, and are associated with mutations in three genes: KRIT1, CCM2, and PDCD10, the protein products of which are KRIT1 (Krev/Rap1 Interaction Trapped 1; CCM1, cerebral cavernous malformations 1), CCM2 (cerebral cavernous malformations 2; OSM, osmosensing scaffold for MEKK3), and CCM3 (cerebral cavernous malformations 3; PDCD10, programmed cell death 10). " 05/01/2014 - "These genes encode for the proteins KRIT1/CCM1 (krev interaction trapped 1/cerebral cavernous malformations 1), cerebral cavernous malformations 2, osmosensing scaffold for MEKK3 (CCM2/malcavernin/OSM), and cerebral cavernous malformations 3/programmed cell death 10 (CCM3/PDCD10). "
3.	Phosphotransferases (Kinase)IBA 01/01/2020 - "Here we report how two novel cytokinetic ring components, GCK-1 (germinal center kinase-1) and CCM-3 (cerebral cavernous malformations-3), participate in a negative feedback loop among RhoA and its cytoskeletal effectors to inhibit contractility. "