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Dysalbuminemic Hyperthyroxinemia

promote to HM

Also Known As:

Hyperthyroxinemia, Dysalbuminemic

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Familial Dysalbuminemic Hyperthyroxinemia: 85
    - Dysalbuminemic Hyperthyroxinemia: 5
Endocrine System Diseases: 968
- Thyroid Diseases: 6126
  - Hyperthyroxinemia: 142
    - Familial Dysalbuminemic Hyperthyroxinemia: 85
      - Dysalbuminemic Hyperthyroxinemia: 5

Related Diseases

1.	Hyperthyroxinemia
2.	Inherited Thyroxine-Binding Globulin Deficiency

Experts

1.	Lim, Ee Mun: 1 article (04/2021)
2.	Ting, Matthew J M: 1 article (04/2021)
3.	Walsh, John P: 1 article (04/2021)
4.	Ward, Bryan K: 1 article (04/2021)
5.	Wilson, Scott G: 1 article (04/2021)
6.	Zhang, Rui: 1 article (04/2021)
7.	Schussler, G C: 1 article (02/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dysalbuminemic Hyperthyroxinemia:

1.	AlbuminsIBA 06/01/1990 - "A recent report documented the existence of three putative types of variant albumin in dysalbuminemic hyperthyroxinemia (DH) and suggested that measurement of the total concentration of three iodothyronines (T4, T3 and rT3) in serum of affected subjects could aid in their differentiation. " 02/01/2000 - "The affinity of albumin for T4 is increased by histidine substitution for arginine 218 in the most common form of dysalbuminemic hyperthyroxinemia. " 09/01/1988 - "In dysalbuminemic hyperthyroxinemia, about 30% of the serum thyroxin is bound to albumin; in prealbumin-associated hyperthyroxinemia, 7% is bound to prealbumin. "
2.	Prealbumin (Transthyretin)IBA 03/01/1990 - "This procedure can be used to help identify TBG excess, TBG deficiency, dysalbuminemic hyperthyroxinemia, prealbumin-associated hyperthyroxinemia, variant TBG with reduced affinity for T4, euthyroid sickness, and T4-binding autoantibodies." 09/01/1988 - "In dysalbuminemic hyperthyroxinemia, about 30% of the serum thyroxin is bound to albumin; in prealbumin-associated hyperthyroxinemia, 7% is bound to prealbumin. "
3.	Thyroxine (Levothyroxine)FDA LinkGeneric 09/01/1988 - "In dysalbuminemic hyperthyroxinemia, about 30% of the serum thyroxin is bound to albumin; in prealbumin-associated hyperthyroxinemia, 7% is bound to prealbumin. "
4.	Proteins (Proteins, Gene)FDA Link 03/01/1990 - "When the concentration of binding proteins was altered (e.g., TBG excess or TBG deficiency), the T4 binding/mass ratio for each protein remained within the expected range; but when the functional affinity of a binding protein was altered--as in dysalbuminemic hyperthyroxinemia and in low-T4 nonthyroidal illness--this ratio was abnormal. "
5.	Histidine (L-Histidine)FDA Link 02/01/2000 - "The affinity of albumin for T4 is increased by histidine substitution for arginine 218 in the most common form of dysalbuminemic hyperthyroxinemia. "
6.	GuanineIBA 04/01/2021 - "Exome sequencing (confirmed by Sanger sequencing) detected a guanine to adenine substitution at residue 725 of the ALB gene previously associated with dysalbuminemic hyperthyroxinemia. "
7.	Carrier Proteins (Binding Protein)IBA 03/01/1990 - "When the concentration of binding proteins was altered (e.g., TBG excess or TBG deficiency), the T4 binding/mass ratio for each protein remained within the expected range; but when the functional affinity of a binding protein was altered--as in dysalbuminemic hyperthyroxinemia and in low-T4 nonthyroidal illness--this ratio was abnormal. "
8.	AutoantibodiesIBA 03/01/1990 - "This procedure can be used to help identify TBG excess, TBG deficiency, dysalbuminemic hyperthyroxinemia, prealbumin-associated hyperthyroxinemia, variant TBG with reduced affinity for T4, euthyroid sickness, and T4-binding autoantibodies."
9.	Arginine (L-Arginine)FDA Link 02/01/2000 - "The affinity of albumin for T4 is increased by histidine substitution for arginine 218 in the most common form of dysalbuminemic hyperthyroxinemia. "
10.	Adenine FDA LinkGeneric 04/01/2021 - "Exome sequencing (confirmed by Sanger sequencing) detected a guanine to adenine substitution at residue 725 of the ALB gene previously associated with dysalbuminemic hyperthyroxinemia. "