Acute Tubulointerstitial Nephritis

A form of tubulointerstitial nephritis characterized by the infiltration of MONONUCLEAR LEUKOCYTES; GLOMERULONEPHRITIS, and reversible kidney failure. Immunologic effects include circulating IMMUNE COMPELXES and non-caseating GRANULOMAS; and laboratory tests reveal elevated urinary microglobulin and elevated seum creatinine. There is a high association with the HLA-DRB1*0102 allele. OMIM: 607665

Networked: 164 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lupus Nephritis
2.	Necrosis
3.	Vasculitis (Vasculitides)
4.	Lipoid Nephrosis (Glomerulonephritis, Minimal Change)
5.	Glomerulonephritis

Experts

1.	Liu, Gang: 5 articles (01/2022 - 04/2010)
2.	Su, Tao: 5 articles (01/2022 - 04/2010)
3.	Yang, Li: 5 articles (01/2022 - 04/2010)
4.	Wang, Su-Xia: 4 articles (01/2022 - 01/2019)
5.	Perazella, Mark A: 4 articles (05/2021 - 04/2004)
6.	Huang, Jun-Wen: 3 articles (01/2022 - 01/2019)
7.	Tang, Jia-Wei: 2 articles (01/2022 - 01/2019)
8.	Zhao, Ming-Hui: 2 articles (01/2022 - 11/2019)
9.	Draibe, Juliana: 2 articles (07/2021 - 06/2020)
10.	Fulladosa, Xavier: 2 articles (07/2021 - 06/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Tubulointerstitial Nephritis:

1.	SteroidsIBA 01/01/2020 - "Renal IrAE is most commonly attributable to steroid responsive acute tubulointerstitial nephritis. " 05/20/2014 - "Renal biopsy confirmed acute tubulointerstitial nephritis and he was started on a course of steroids with renal recovery in 72 h. " 11/01/2012 - "The use and timing of steroids in the management of acute tubulointerstitial nephritis (ATIN) remains debatable. " 11/01/2012 - "Acute tubulointerstitial nephritis, treatment with steroid and impact on renal outcomes." 01/01/1989 - "Acute tubulointerstitial nephritis and uveitis responded dramatically to steroid therapy. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/27/2023 - "Clinical features, outcomes, and response to corticosteroid treatment of acute tubulointerstitial nephritis: a single centre retrospective cohort study in Czech Republic." 02/01/2018 - "In both cases, the pathologic diagnosis was acute tubulointerstitial nephritis, and corticosteroid therapy resulted in improved renal function. " 11/01/2023 - "Favorable course of leptospirosis and hantavirus-induced acute tubulointerstitial nephritis under corticosteroid treatment." 01/01/1989 - "A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy." 01/01/2020 - "Immune checkpoint inhibitor discontinuation and corticosteroid therapy are recommended for acute tubulointerstitial nephritis. "
3.	GlucocorticoidsIBA 01/01/2016 - "Among the 12 patients with acute tubulointerstitial nephritis, 10 received treatment with glucocorticoids, resulting in complete or partial improvement in renal function in 2 and 7 patients, respectively. " 01/01/2016 - "However, the 2 patients with acute tubulointerstitial nephritis not given glucocorticoids had no improvement in renal function. " 01/01/2022 - "It means that ICIs possibly induce not only acute tubulointerstitial nephritis but also nephrotic syndrome due to MN as renal irAEs which is treatable with glucocorticoid."
4.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/01/1989 - "Because no prospective study of treatment for NSAID-induced acute tubulointerstitial nephritis has been performed, the efficacy of steroid therapy remains uncertain."
5.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 11/01/2019 - "Acute tubulointerstitial nephritis with germinal centers in antineutrophil cytoplasmic antibody-associated vasculitis: A case report and literature review." 03/01/2019 - "Acute tubulointerstitial nephritis (61.1%) was the most common tubulointerstitial disease, whereas antineutrophil cytoplasmic antibody vasculitis (56.3%) was the most common vascular nephropathy. " 07/01/1996 - "Acute tubulointerstitial nephritis and uveitis with antineutrophil cytoplasmic antibody." 09/01/2015 - "This study investigated the variations of Tregs Foxp3+ in the kidney biopsies inflammatory infiltrate of different lupus nephritis classes compared to that of ANCA glomerulonephritis, acute tubulointerstitial nephritis and nephroangiosclerosis. " 01/01/2007 - "In other words, MPO ANCA-related nephritis is a condition that involves "acute glomerulonephritis+ acute tubulointerstitial nephritis + angiitis," and it is thought that the characteristics of each are independent. "
6.	CalciumIBA 06/01/2021 - "It has a wide spectrum of presentation including abnormal calcium metabolism, nephrolithiasis, nephrocalcinosis, and acute tubulointerstitial nephritis with or without granulomas. " 01/01/1993 - "Metabolism of calcium and vitamin D3 in patients with acute tubulointerstitial nephritis: a study of 41 patients with nephropathia epidemica."
7.	Antigen-Antibody Complex (Immune Complex)IBA 03/01/2009 - "We report a case of acute tubulointerstitial nephritis with giant cell tubulitis and tubular basement membrane immune complex deposits in a patient with membranous lupus nephritis. " 05/01/2023 - "The study group included 17 patients with a range of conditions including immune-complex-mediated kidney diseases (IgA nephropathy, membranous nephropathy and lupus nephritis), podocytopathy (minimal change disease and focal segmental glomerulosclerosis) and others (antineutrophil-cytoplasmic-antibody-associated vasculitis, anti-glomerular basement membrane nephritis, acute tubulointerstitial nephritis and thrombotic microangiopathy). "
8.	LectinsIBA 12/01/1989 - "Acute tubulointerstitial nephritis in children: clinical, morphologic, and lectin studies. "
9.	TenascinIBA 01/01/1996 - "In this study, the expression of tenascin in the renal interstitium was immunohistochemically evaluated in 208 renal specimens during normal kidney (23 cases), acute tubular necrosis (8), acute tubulointerstitial nephritis (8), chronic primary tubulointerstitial nephritis (30), tubulointerstitial nephritis secondary to glomerular diseases of mild (46) and severe (55) degree, ischemic damage (24), and rejection (14). "
10.	Cholecalciferol (Vitamin D3)FDA Link 01/01/1993 - "Metabolism of calcium and vitamin D3 in patients with acute tubulointerstitial nephritis: a study of 41 patients with nephropathia epidemica."

Therapies and Procedures

1.	Therapeutics 01/01/2020 - "Renal injury from chemotherapy is often ascribed to acute tubular injury and necrosis, whereas the main mechanism of injury caused by ICI therapy is acute tubulointerstitial nephritis. " 02/01/2018 - "In both cases, the pathologic diagnosis was acute tubulointerstitial nephritis, and corticosteroid therapy resulted in improved renal function. " 06/01/2010 - "Acute tubulointerstitial nephritis (ATIN) as a complication of antituberculous therapy has been most commonly reported due to rifampicin therapy. " 04/01/2007 - "Acute tubulointerstitial nephritis associated with long-term gemcitabine therapy." 04/01/2000 - "Acute tubulointerstitial nephritis attributable to indinavir therapy."
2.	Immunotherapy 05/31/2021 - "This case highlights the importance of recognizing acute tubulointerstitial nephritis as a side effect of immunotherapy for prompt diagnosis and early treatment." 05/31/2021 - "Immunotherapy-Induced Acute Tubulointerstitial Nephritis." 01/01/2021 - "In this case report, we describe the first known instance of a patient being treated with an inhibitor of programmed death-ligand 1 (anti-PD-L1, a checkpoint inhibitor) who develops acute tubulointerstitial nephritis after contracting the severe acute respiratory syndrome coronavirus 2. A 62-year-old patient, on immunotherapy treatment for stage 4 squamous cell carcinoma, presents to the emergency department with symptoms of lower respiratory tract infection. " 01/01/2020 - "Acute tubulointerstitial nephritis and IgM deposits on glomerular capillary walls after immunotherapy with nivolumab for metastatic renal cell carcinoma."
3.	Drug Therapy (Chemotherapy) 06/01/2010 - "Acute tubulointerstitial nephritis related to antituberculous drug therapy." 01/01/2020 - "Renal injury from chemotherapy is often ascribed to acute tubular injury and necrosis, whereas the main mechanism of injury caused by ICI therapy is acute tubulointerstitial nephritis. " 03/15/2021 - "BACKGROUND Acute tubulointerstitial nephritis is most often induced by drug therapy and is characterized by the presence of edema, inflammatory infiltrates, and sometimes granulomas within the interstitium. "
4.	Aftercare (After-Treatment) 01/01/2013 - "To date, the development of biopsy-proven acute tubulointerstitial nephritis after treatment with exenatide has not been reported. " 05/01/2014 - "We report on a patient with late onset-acute tubulointerstitial nephritis (ATIN) after treatment with infliximab and mesalazine for Crohn's disease. " 01/01/2012 - "Dress syndrome and acute tubulointerstitial nephritis after treatment with vancomycin and beta-lactams. "
5.	Slit Lamp 06/01/2022 - "A diagnostic kidney biopsy confirmed acute tubulointerstitial nephritis, and a slit-lamp examination confirmed acute left anterior uveitis consistent with a diagnosis of TINU. "