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Familial Progressive Hyperpigmentation

Also Known As:

Hyperpigmentation, Familial Progressive; Melanosis Universalis Hereditaria

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Pigmentation Disorders: 149
    - Hyperpigmentation: 3268
      - Familial Progressive Hyperpigmentation: 5

Related Diseases

1.	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
2.	Cutaneous Mastocytosis
3.	Hearing Loss (Hearing Impairment)
4.	Hypopigmentation (Hypomelanosis)
5.	Waardenburg syndrome type 2

Experts

1.	Akın, R: 1 article (09/2022)
2.	Bademci, G: 1 article (09/2022)
3.	Bozan, N: 1 article (09/2022)
4.	Doosti, M: 1 article (09/2022)
5.	Douzgou, S: 1 article (09/2022)
6.	Duman, D: 1 article (09/2022)
7.	Girisha, K M: 1 article (09/2022)
8.	Houlden, H: 1 article (09/2022)
9.	Karimiani, E G: 1 article (09/2022)
10.	Lewis, S S: 1 article (09/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Progressive Hyperpigmentation:

1.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/01/2009 - "A kindred with familial progressive hyperpigmentation-like disorder: implication of fibroblast-derived growth factors in pigmentation."
2.	Stem Cell FactorIBA 05/01/2009 - "Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation."
3.	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA 01/01/2017 - "Familial Progressive Hyperpigmentation, Cutaneous Mastocytosis, and Gastrointestinal Stromal Tumor as Clinical Manifestations of Mutations in the c-KIT Receptor Gene."
4.	Proteins (Proteins, Gene)FDA Link 09/01/2022 - "Pathogenic variants in KITLG, a crucial protein involved in pigmentation and neural crest cell migration, cause non-syndromic hearing loss, Waardenburg syndrome type 2, familial progressive hyperpigmentation and familial progressive hyper- and hypopigmentation, all of which are inherited in an autosomal dominant manner. "
5.	Melanins (Melanin)IBA 05/01/2009 - "Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation."
6.	Imatinib Mesylate (Gleevec)FDA Link 10/14/2022 - "Familial progressive hyperpigmentation: Skin lightening due to imatinib."