Odontohypophosphatasia

Networked: 13 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Inborn Errors Metabolism: 1162
    - Inborn Errors Metal Metabolism
      - Hypophosphatasia: 737
        Odontohypophosphatasia: 13
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Inborn Errors Metabolism: 1162
    - Inborn Errors Metal Metabolism
      - Hypophosphatasia: 737
        Odontohypophosphatasia: 13
Stomatognathic Diseases: 705
- Tooth Diseases: 33
  - Tooth Demineralization: 59
    - Odontohypophosphatasia: 13

Related Diseases

1.	Oral Manifestations
2.	Hypophosphatasia

Experts

1.	Salles, Jean Pierre: 2 articles (02/2020 - 01/2015)
2.	Gawlik, Aneta: 1 article (03/2022)
3.	Lewiński, Andrzej: 1 article (03/2022)
4.	Michałus, Izabela: 1 article (03/2022)
5.	Wieczorek-Szukała, Katarzyna: 1 article (03/2022)
6.	Akiyama, Tomoyuki: 1 article (01/2020)
7.	Iwayama, Hideyuki: 1 article (01/2020)
8.	Kato, Shunsuke: 1 article (01/2020)
9.	Muto, Taichiro: 1 article (01/2020)
10.	Okumura, Akihisa: 1 article (01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Odontohypophosphatasia:

1.	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 03/30/2022 - "In the study group, one patient was diagnosed with perinatal type of HPP, three were diagnosed with infant variant, eight were diagnosed with children variant, two were diagnosed with odontohypophosphatasia, and two were diagnosed with the adult type of the disease. " 07/01/2023 - "Odontohypophosphatasia (odonto-HPP) is a mild form of HPP characterized by oral symptoms, such as premature loss of primary teeth. " 02/01/2020 - "Dental clinical presentations, which include the premature loss of teeth, are also commonly found in HPP and specifically manifest as odontohypophosphatasia. " 01/01/2016 - "HPP is classified into six forms according to the age of onset and severity as perinatal (lethal), perinatal benign, infantile, childhood, adult, and odontohypophosphatasia. " 05/01/2015 - "In addition to skeletal defects, HPP causes dental defects, and a mild clinical form of HPP, odontohypophosphatasia, features only a dental phenotype. "
2.	Alkaline PhosphataseIBA 08/01/2003 - "Molecular study of three cases of odontohypophosphatasia resulting from heterozygosity for mutations in the tissue non-specific alkaline phosphatase gene." 08/01/2017 - "Genetic evaluations of Chinese patients with odontohypophosphatasia resulting from heterozygosity for mutations in the tissue-non-specific alkaline phosphatase gene." 08/01/2015 - "Molecular phenotype of tissue-nonspecific alkaline phosphatase with a proline (108) to leucine substitution associated with dominant odontohypophosphatasia."
3.	Proline (L-Proline)FDA Link 08/01/2015 - "Molecular phenotype of tissue-nonspecific alkaline phosphatase with a proline (108) to leucine substitution associated with dominant odontohypophosphatasia."
4.	Leucine (L-Leucine)FDA Link 08/01/2015 - "Molecular phenotype of tissue-nonspecific alkaline phosphatase with a proline (108) to leucine substitution associated with dominant odontohypophosphatasia."
5.	asfotase alfaIBA 01/01/2020 - "Odontohypophosphatasia treated with asfotase alfa enzyme replacement therapy in a toddler: a case report."

Therapies and Procedures

1.	Therapeutics 05/01/2015 - "The Alpl(+/A116T) mouse is the first model of odontohypophosphatasia, providing insights on dentoalveolar development and function under reduced ALP, bringing attention to direct effects of HPP on alveolar bone, and offering a new model for testing potential dental-targeted therapies in future studies. "
2.	Enzyme Replacement Therapy 01/01/2020 - "Odontohypophosphatasia treated with asfotase alfa enzyme replacement therapy in a toddler: a case report."