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Myopia 5

Also Known As:

MYP5

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Eye Diseases: 3522
- Refractive Errors: 3499
  - Myopia: 8363
    - Myopia 5: 11

Related Diseases

1.	Myopia
2.	Hyperopia (Hypermetropia)
3.	Prolapse
4.	Keratitis
5.	Pathologic Dilatation (Ectasia)

Experts

1.	Fielder, Alistair: 1 article (10/2021)
2.	Fleck, Brian: 1 article (10/2021)
3.	Lepore, Domenico: 1 article (10/2021)
4.	Marlow, Neil: 1 article (10/2021)
5.	RAINBOW investigators group: 1 article (10/2021)
6.	Reynolds, James D: 1 article (10/2021)
7.	Stahl, Andreas: 1 article (10/2021)
8.	Stiehl, Daniel P: 1 article (10/2021)
9.	Weisberger, Annemarie: 1 article (10/2021)
10.	Zhu, Qi: 1 article (10/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myopia 5:

1.	4-hexyloxyaniline (HOA)IBA 03/01/2006 - "Aberrometric findings after wavefront-guided LASIK in patients with lower preoperative HOA and myopia > 5 D (SE) are comparable with the results after standard treatment." 04/01/2018 - "The IR and Non-IR groups were subcategorized depending on the spherical equivalent (lower myopia ≤-5.00 D vs. higher myopia >-5.00 D) for the comparison of HOA changes. "
2.	Retinaldehyde (Retinal)IBA 01/01/1992 - "The occurrence of a defect (nerve fiber loss) in the retinal nerve fiber layer in severe myopia (5/59, 8%) was also greater than that in either emmetropia or hyperopia (2/144, 1%; P = 0.0229). "
3.	Proteoglycans (Proteoglycan)IBA 03/01/2016 - "The various factors affecting eye growth are shown in 5 simulations: (1 - unregulated eye growth): blur feedback is rendered ineffective, as in the case of form deprivation, so there is only genetically pre-programmed eye growth, generally resulting in myopia; (2 - regulated eye growth): blur feedback regulation demonstrates the emmetropization process, with abnormally excessive or reduced eye growth leading to myopia and hyperopia, respectively; (3 - repeated near-far viewing): simulation of large-to-small change in blur size as seen in the accommodative stimulus/response function, and via IRDT as well as nearwork-induced transient myopia (NITM), leading to the development of myopia; (4 - neurochemical bulk flow and diffusion): release of dopamine from the inner plexiform layer of the retina, and the subsequent diffusion and relay of neurochemical cascade show that a decrease in dopamine results in a reduction of proteoglycan synthesis rate, which leads to myopia; (5 - Simulink model): model of genetically pre-programmed signaling and blur feedback components that allows for different input functions to simulate experimental manipulations that result in hyperopia, emmetropia, and myopia. "
4.	Dopamine (Intropin)FDA LinkGeneric 03/01/2016 - "The various factors affecting eye growth are shown in 5 simulations: (1 - unregulated eye growth): blur feedback is rendered ineffective, as in the case of form deprivation, so there is only genetically pre-programmed eye growth, generally resulting in myopia; (2 - regulated eye growth): blur feedback regulation demonstrates the emmetropization process, with abnormally excessive or reduced eye growth leading to myopia and hyperopia, respectively; (3 - repeated near-far viewing): simulation of large-to-small change in blur size as seen in the accommodative stimulus/response function, and via IRDT as well as nearwork-induced transient myopia (NITM), leading to the development of myopia; (4 - neurochemical bulk flow and diffusion): release of dopamine from the inner plexiform layer of the retina, and the subsequent diffusion and relay of neurochemical cascade show that a decrease in dopamine results in a reduction of proteoglycan synthesis rate, which leads to myopia; (5 - Simulink model): model of genetically pre-programmed signaling and blur feedback components that allows for different input functions to simulate experimental manipulations that result in hyperopia, emmetropia, and myopia. "
5.	CollagenIBA 09/01/2007 - "The collagen type Iota alpha Iota (COL1A1) gene encodes the extracellular matrix component, collagen, and resides in candidate MYP5 for high myopia on the chromosome 17q22-q23.3. "
6.	Ranibizumab (Lucentis)FDA Link 10/01/2021 - "The odds ratio of no structural abnormality was 5·68 (95% CI 0·60-54·0; p=0·10) for ranibizumab 0·2 mg versus laser therapy, 4·82 (0·52-45·0; p=0·14) for ranibizumab 0·1 mg versus laser therapy, and 1·21 (0·07-20; p=0·90) for ranibizumab 0·2 mg vs 0·1 mg. High myopia (-5 dioptres or worse) was less frequent after 0·2 mg ranibizumab (five [5%] of 110 eyes) than with laser therapy (16 [20%] of 82; odds ratio 0·19, 95% CI 0·05-0·69; p=0·012). "

Therapies and Procedures

1.	Laser In Situ Keratomileusis (LASIK) 01/01/2010 - "The 48-year-old man had undergone LASIK to correct high myopia 5 years earlier. " 05/01/2008 - "The following complications were observed: epithelial ingrowth into the interface with or without melting of the flap (6 cases), corneal ectasia (2 cases), dislocation of a phakic posterior chamber intraocular lens and prolapse into the anterior chamber with endothelial cell loss (1 case), secondary increase of intraocular pressure following implantation of a phakic intraocular lens (1 case), flap-related complications following laser-in-situ keratomileusis (LASIK) (2 cases), keratitis (1 case), dislocation of the complete flap (1 case), diffuse lamellar keratitis (DLK) grade IV (1 case), hyperopia as a consequence of radial keratotomy (1 case), and under correction/over correction and poor optical quality following laser epithelial keratomileusis (LASEK) and LASIK for high myopia (5 cases) with possible early corneal ectasia. " 03/01/2006 - "Aberrometric findings after wavefront-guided LASIK in patients with lower preoperative HOA and myopia > 5 D (SE) are comparable with the results after standard treatment."
2.	Intraocular Lenses (Intraocular Lens) 08/01/2001 - "To evaluate the effectiveness of the surgical correction of high myopia 5 years after anterior chamber intraocular lens (IOL) implantation and to analyze the lens position and related complications. " 05/01/2008 - "The following complications were observed: epithelial ingrowth into the interface with or without melting of the flap (6 cases), corneal ectasia (2 cases), dislocation of a phakic posterior chamber intraocular lens and prolapse into the anterior chamber with endothelial cell loss (1 case), secondary increase of intraocular pressure following implantation of a phakic intraocular lens (1 case), flap-related complications following laser-in-situ keratomileusis (LASIK) (2 cases), keratitis (1 case), dislocation of the complete flap (1 case), diffuse lamellar keratitis (DLK) grade IV (1 case), hyperopia as a consequence of radial keratotomy (1 case), and under correction/over correction and poor optical quality following laser epithelial keratomileusis (LASEK) and LASIK for high myopia (5 cases) with possible early corneal ectasia. "
3.	Telescopes 09/01/2023 - "Age and sex-matched children with binocular emmetropia (-0.5D < spherical equivalence [SE] < 0.5D), low myopia (-5.0D < SE ≤ -0.5D), and high myopia (SE ≤ -5.0D), as well as their parents, were enrolled. "
4.	Phakic Intraocular Lenses 05/01/2008 - "The following complications were observed: epithelial ingrowth into the interface with or without melting of the flap (6 cases), corneal ectasia (2 cases), dislocation of a phakic posterior chamber intraocular lens and prolapse into the anterior chamber with endothelial cell loss (1 case), secondary increase of intraocular pressure following implantation of a phakic intraocular lens (1 case), flap-related complications following laser-in-situ keratomileusis (LASIK) (2 cases), keratitis (1 case), dislocation of the complete flap (1 case), diffuse lamellar keratitis (DLK) grade IV (1 case), hyperopia as a consequence of radial keratotomy (1 case), and under correction/over correction and poor optical quality following laser epithelial keratomileusis (LASEK) and LASIK for high myopia (5 cases) with possible early corneal ectasia. "
5.	Excimer Lasers 07/01/1999 - "[Excimer laser photorefractive keratectomy for lower to moderate myopia: 5 year follow-up]."