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2 Hypomyelinating Leukodystrophy

Also Known As:

Leukodystrophy, Hypomyelinating, 2; Pelizaeus-Merzbacher-Like Disease, 1

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Inborn Errors Metabolism: 1162
    - Inborn Metabolic Brain Diseases: 2
      - Hereditary Central Nervous System Demyelinating Diseases
        2 Hypomyelinating Leukodystrophy: 1
  - Nervous System Heredodegenerative Disorders: 63
    - Hereditary Central Nervous System Demyelinating Diseases
      - 2 Hypomyelinating Leukodystrophy: 1
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Inborn Errors Metabolism: 1162
    - Inborn Metabolic Brain Diseases: 2
      - Hereditary Central Nervous System Demyelinating Diseases
        2 Hypomyelinating Leukodystrophy: 1
  - Metabolic Brain Diseases: 215
    - Inborn Metabolic Brain Diseases: 2
      - Hereditary Central Nervous System Demyelinating Diseases
        2 Hypomyelinating Leukodystrophy: 1

Related Diseases

1.	Paraplegia (Spastic Paraplegia)

Experts

1.	Garbern, James Y: 1 article (02/2012)
2.	Hobson, Grace M: 1 article (02/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to 2 Hypomyelinating Leukodystrophy:

1.	ConnexinsIBA 02/01/2012 - "A similar constellation of signs and pattern of hypomyelination lead to the autosomal recessive disease called Pelizaeus-Merzbacher-like disease 1 (PMLD1) and the less-severe spastic paraplegia 44 (SPG44), caused by mutations of the gap junction protein, gamma-2 gene (GJC2), formerly known as the gap junction protein, α-12 gene (GJA12). "