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Poor Metabolism of Proguanil

mutation in CYP2C19

Also Known As:

Proguanil, Poor Metabolism of

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Inborn Errors Metabolism: 1162
    - Poor Metabolism of Proguanil: 3
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Inborn Errors Metabolism: 1162
    - Poor Metabolism of Proguanil: 3

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Poor Metabolism of Proguanil:

1.	Cytochrome P-450 CYP2C19IBA 06/01/1999 - "In conclusion, our data demonstrate an association between CYP2C19 mutations and poor metabolism of proguanil." 03/29/1997 - "High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu." 04/01/1999 - "Mutations in human CYP2C19 and parasite dihydrofolate reductase (dhfr) genes, related to poor metabolism of proguanil and resistance to cycloguanil, respectively, have both been assumed to be associated with poor antimalarial effect by proguanil. "
2.	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 04/01/1999 - "Mutations in human CYP2C19 and parasite dihydrofolate reductase (dhfr) genes, related to poor metabolism of proguanil and resistance to cycloguanil, respectively, have both been assumed to be associated with poor antimalarial effect by proguanil. "
3.	Proguanil (Paludrine)FDA Link 04/01/1999 - "Mutations in human CYP2C19 and parasite dihydrofolate reductase (dhfr) genes, related to poor metabolism of proguanil and resistance to cycloguanil, respectively, have both been assumed to be associated with poor antimalarial effect by proguanil. "
4.	Antimalarials (Antimalarial Agents)IBA 04/01/1999 - "Mutations in human CYP2C19 and parasite dihydrofolate reductase (dhfr) genes, related to poor metabolism of proguanil and resistance to cycloguanil, respectively, have both been assumed to be associated with poor antimalarial effect by proguanil. "
5.	cycloguanilIBA 04/01/1999 - "Mutations in human CYP2C19 and parasite dihydrofolate reductase (dhfr) genes, related to poor metabolism of proguanil and resistance to cycloguanil, respectively, have both been assumed to be associated with poor antimalarial effect by proguanil. "