Age-Related Nuclear Cataract

11/01/2018 - "Our findings suggest that the microcirculation system can potentially be harnessed to deliver exogenous antioxidants to the lens core to afford mature fiber cells protection against oxidative damage that ultimately manifests as age-related nuclear cataract."
03/01/2007 - "This newly identified pathway opens an opportunity for the delivery of therapeutic antioxidants aimed at preventing age-related nuclear cataract."
01/01/2019 - "The reduced levels of antioxidants, UV filters, and osmolytes were found in the cataractous lenses what cannot be explained by post-mortem changes in normal lens; that indicates that the age-related nuclear cataract development may originate from the dysfunction of the lens epithelial cells."
01/01/2017 - "Reactive oxygen species (ROS) production, lipid peroxidation, reduction of antioxidant enzymes, crystalline proteolysis, and apoptosis are considered factors that contribute to pathogenesis of age-related nuclear cataract. "

07/14/2012 - "The aim of the present study was to examine whether plasma concentrations of lutein and zeaxanthin are related to age-related nuclear cataract in the elderly population. "
07/14/2012 - "In conclusion, we suggest that high plasma concentrations of lutein and zeaxanthin were associated with a decreased risk of age-related nuclear cataract in the elderly population."
07/14/2012 - "The association of plasma lutein and zeaxanthin concentrations with age-related nuclear cataract in 1689 elderly subjects (aged 61-80 years) was investigated in the present cross-sectional study by using the Cox proportional hazards model. "
07/14/2012 - "Plasma lutein and zeaxanthin and the risk of age-related nuclear cataract among the elderly Finnish population."
03/01/2008 - "Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative."

07/14/2012 - "The aim of the present study was to examine whether plasma concentrations of lutein and zeaxanthin are related to age-related nuclear cataract in the elderly population. "
07/14/2012 - "In conclusion, we suggest that high plasma concentrations of lutein and zeaxanthin were associated with a decreased risk of age-related nuclear cataract in the elderly population."
07/14/2012 - "The association of plasma lutein and zeaxanthin concentrations with age-related nuclear cataract in 1689 elderly subjects (aged 61-80 years) was investigated in the present cross-sectional study by using the Cox proportional hazards model. "
07/14/2012 - "Plasma lutein and zeaxanthin and the risk of age-related nuclear cataract among the elderly Finnish population."
03/01/2008 - "Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative."

02/01/1999 - "The relations of serum carotenoids and tocopherols to the incidence of age-related nuclear cataract were investigated in a random sample of 400 adults, 50-86 y of age, in the Beaver Dam Eye Study. "
02/01/1999 - "Serum carotenoids and tocopherols and incidence of age-related nuclear cataract."
03/01/2008 - "Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative."

05/01/1998 - "The aim of this study was to determine if the unusual coloured species characteristic of age-related nuclear cataract could be localised to specific residues of the crystallins. "
03/01/2002 - "Oxidative damage to lens proteins is associated with human age-related nuclear cataract and H2O2 has been implicated. "
12/01/2015 - "In conclusion, the β-crystallin disulfidome is highly conserved in age-related nuclear cataract and LEGSKO mouse, and reproducible by in vitro oxidation, whereas some of the disulfide formation sites in γ-crystallins necessitate prior conformational changes. "
12/01/2015 - "Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract. "
12/01/1997 - "Molecular evidence for the involvement of alpha crystallin in the colouration/crosslinking of crystallins in age-related nuclear cataract."

04/13/2018 - "This study is aimed to screen out the microRNAs (miRNAs) associated with H2O2 induced oxidative stress in human lens epithelial B3 (HLE-B3) cell lines and investigate their relations with the progression of age-related nuclear cataract. "
04/13/2018 - "Identification of H2O2 induced oxidative stress associated microRNAs in HLE-B3 cells and their clinical relevance to the progression of age-related nuclear cataract."
03/05/2022 - "This miRNA is also involved in the pathoetiology of IgA nephropathy, obstructive sleep apnea, age-related nuclear cataract and vitiligo. "

02/01/1999 - "The relations of serum carotenoids and tocopherols to the incidence of age-related nuclear cataract were investigated in a random sample of 400 adults, 50-86 y of age, in the Beaver Dam Eye Study. "
02/01/1999 - "Serum carotenoids and tocopherols and incidence of age-related nuclear cataract."

11/15/2014 - "Previous linkage and candidate gene studies suggested genetic influences on age-related nuclear cataract but few genetic markers have been identified thus far. "

01/01/2021 - "This study indicates that the spatial and temporal calcium precipitation is an age-related event associated with age-related nuclear cataract formation in Cx46KO mice, and further suggests that the loss of Cx46 promotes calcium precipitates in the lens core, which is a new mechanism that likely contributes to the pathological light scattering in this age-related cataract model."

09/01/2019 - "The purpose of this study was to explore the effects of Tanshinone IIA on age-related nuclear cataract. "

01/01/2016 - "In this study, we assessed 30 binocular age-related nuclear cataract patients (aged 72.5 ± 7.2, 16 female) who were eligible for cataract surgery. "

10/01/2017 - "Fluorescence intensity profiles measured along the optical axis of human eye lenses with age-related nuclear cataract showed increasing concentration of fluorescent PTM towards the lens centre in accord with the increased optical density in the lens nucleolus. "
01/01/2019 - "Comparison of the metabolomic compositions of lenses and AH taken from cataract patients with that taken from human cadavers without cataract can shed light onto molecular mechanisms underlying onset of age-related nuclear cataract. "
01/01/2021 - "Hyperbaric oxygen (HBO) treatment of animals or ocular lenses in culture recapitulates many molecular changes observed in human age-related nuclear cataract. "
01/01/2019 - "The reduced levels of antioxidants, UV filters, and osmolytes were found in the cataractous lenses what cannot be explained by post-mortem changes in normal lens; that indicates that the age-related nuclear cataract development may originate from the dysfunction of the lens epithelial cells."
01/01/2009 - "Changes in ferritin H- and L-chains in canine lenses with age-related nuclear cataract."

02/01/2017 - "A total of 51 eyes (34 patients) with age-related nuclear cataract had phacoemulsification. "
07/01/2009 - "To evaluate the relationship between lens density measured using the Pentacam Scheimpflug system and phacodynamics (phacoemulsification time, phacoemulsification energy, and balanced salt solution [BSS] use) in patients with age-related nuclear cataract. "

01/01/2021 - "We have applied synchrotron phase contrast X-ray micro-computed tomography to directly examine an age-related nuclear cataract model in Cx46 knockout (Cx46KO) mice. "

11/01/2007 - "Enhancing the delivery of glycine to the core via the sutures may represent a pathway to protect the lens against the protein modifications associated with age-related nuclear cataract."