2 Noninsulin-Dependent Diabetes Mellitus

A hereditary predisposition to type II diabetes has been mapped to chromosome 12q. OMIM: 601407

Also Known As:

Diabetes Mellitus, Noninsulin-Dependent, 2; NIDDM2; Noninsulin-Dependent Diabetes Mellitus 2

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Glucose Metabolism Disorders: 375
    - Diabetes Mellitus: 56563
      - Type 2 Diabetes Mellitus: 95492
        2 Noninsulin-Dependent Diabetes Mellitus: 18
Endocrine System Diseases: 968
- Diabetes Mellitus: 56563
  - Type 2 Diabetes Mellitus: 95492
    - 2 Noninsulin-Dependent Diabetes Mellitus: 18

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY)
2.	Type 3 Maturity-Onset Diabetes of the Young
3.	3 Noninsulin-Dependent Diabetes Mellitus
4.	1 Noninsulin-Dependent Diabetes Mellitus
5.	Overweight

Experts

1.	Gragnoli, Claudia: 4 articles (01/2013 - 02/2010)
2.	Aumüller, Eva: 1 article (10/2012)
3.	Brath, Helmut: 1 article (10/2012)
4.	Haslberger, Alexander G: 1 article (10/2012)
5.	Müllner, Elisabeth: 1 article (10/2012)
6.	Switzeny, Olivier J: 1 article (10/2012)
7.	Wagner, Karl-Heinz: 1 article (10/2012)
8.	Cronsell, J: 1 article (09/2007)
9.	Gragnoli, C: 1 article (09/2007)
10.	Almgren, Peter: 1 article (08/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to 2 Noninsulin-Dependent Diabetes Mellitus:

1.	Insulin (Novolin)FDA Link 02/01/2010 - "PSMD9 (which rarely causes T2D in Italians) lies in the NIDDM2 region and is implicated in beta cell insulin transcription and diabetes onset in mice. " 01/03/2013 - "Obesity and obesity-associated phenotypes are linked to the chromosome12q24 locus, the non-insulin-dependent-diabetes 2 (NIDDM2) locus. " 04/17/2011 - "The same chromosome region entails at least a major risk gene for type 2 diabetes (T2D) within NIDDM2, the non-insulin-dependent-diabetes 2 locus. " 02/01/2010 - "Type 2 diabetes (T2D) has a replicated linkage on chromosome12q24.2, the non-insulin-dependent-diabetes 2 (NIDDM2) locus. " 02/15/1997 - "Taken together with our recent findings of linkage between this region on chromosome 12 and an insulin-deficient form of NIDDM (NIDDM2), the data suggest that mutations at the MODY3/NIDDM2 gene(s) result in a reduced insulin secretory response, that subsequently progresses to diabetes and underlines the importance of subphenotypic classification in studies of diabetes."
2.	Glucose (Dextrose)FDA LinkGeneric 08/01/2005 - "The gene for MODY3 diabetes, HNF1alpha, lies in a region that has shown linkage to late-onset type 2 diabetes (12q24, NIDDM2), and previous association studies have suggested a weak trend toward association for common missense variants in HNF1alpha with glucose-related traits. " 02/01/1986 - "Of 86 seen 3 months after delivery, 2 had developed insulin-dependent diabetes mellitus (IDDM) and 2 noninsulin dependent diabetes mellitus (NIDDM), diagnosed by glucose tolerance testing. " 10/01/1992 - "Whole-body glucose utilization in NIDDM patients--NIDDM4 versus NIDDM3 versus NIDDM2 versus NIDDM1 versus controls--was: 1.86 +/- 0.31 versus 2.21 +/- 0.39 versus 2.01 +/- 0.40 versus 5.98 +/- 0.77 versus 5.52 +/- 0.92 mg/kg/min (mean +/- SE). " 06/01/1999 - "Metformin has been used for over 40 years as an effective glucose-lowering agent in type 2 (noninsulin-dependent) diabetes mellitus. " 02/01/1993 - "The level of sex hormone-binding globulin (SHBG) is associated with glucose metabolism in nondiabetic women and men, and the finding of low SHBG levels is suggested to be a predictor of the development of type 2 (noninsulin-dependent) diabetes mellitus. "
3.	Proteasome Endopeptidase Complex (Proteasome)IBA 04/17/2011 - "The gene of proteasome modulator 9 (PSMD9) lies in the NIDDM2 region and is implicated in diabetes in mice. " 01/03/2013 - "The gene of proteasome modulator 9 (PSMD9) lies in the NIDDM2 region and is linked to type 2 diabetes (T2D), microvascular and macrovascular complications of T2D.We aimed at studying whether the PSMD9 T2D risk single nucleotide polymorphisms (SNPs) IVS3+nt460, IVS3+nt437, and 197G are linked to obesity, overweight status and waist circumference in Italian T2D families. " 09/01/2007 - "Within NIDDM2 we examined the PSMD9 (proteasome modulator 9/Bridge-1) gene that encodes a PDZ-domain transcriptional coactivator of insulin production. "
4.	C-PeptideIBA 01/01/1986 - "Serum C-peptide concentrations were determined in 121 elderly subjects: 25 nondiabetic controls aged 69-86 years, and 96 type 2 (noninsulin-dependent diabetes mellitus) diabetics aged 64-96 years. " 01/01/1998 - "127 hospitalized NIDDM patients subdivided to the following subgroups: non-obese with C-peptide < 0.3 nmol/l (NIDDM-(-)), non-obese with C-peptide > 0.3 nmol/l (NIDDM-(+)), obese with C-peptide < 0.3 nmol/l (NIDDM+(-)) and obese with C-peptide > 0.3 nmol/l (NIDDM2+). "
5.	Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)IBA 04/01/2010 - "Type 2 diabetes has a replicated linkage on chromosome12q24.2 (NIDDM2 locus/non-insulin-dependent diabetes mellitus 2 locus), near the HNF-1alpha/MODY3 gene. "
6.	Sex Hormone-Binding GlobulinIBA 02/01/1993 - "The level of sex hormone-binding globulin (SHBG) is associated with glucose metabolism in nondiabetic women and men, and the finding of low SHBG levels is suggested to be a predictor of the development of type 2 (noninsulin-dependent) diabetes mellitus. "
7.	Metformin (Glucophage)FDA LinkGeneric 06/01/1999 - "Metformin has been used for over 40 years as an effective glucose-lowering agent in type 2 (noninsulin-dependent) diabetes mellitus. "
8.	Hypoglycemic Agents (Hypoglycemics)IBA 01/01/2005 - "Agents with alpha-glucosidase inhibitory activity have been useful as oral hypoglycemic drugs for the control of hyperglycemia in patients with type 2; noninsulin-dependent, diabetes mellitus (NIDDM). "
9.	GlucokinaseIBA 01/01/1995 - "The population association of glucokinase gene with type 2 (noninsulin-dependent) diabetes mellitus in Chinese."
10.	Blood Glucose (Blood Sugar)IBA 11/01/2000 - "Although the diagnosis of type 2 (noninsulin-dependent) diabetes mellitus is made when blood glucose levels exceed values which increase the risk of microvascular complications, macrovascular disease is the major complication of type 2 diabetes mellitus. "