X-Linked 3 Mental Retardation

Also Known As:

Mental Retardation, X-Linked 3; MRX3

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Neurologic Manifestations: 7102
  - Neurobehavioral Manifestations: 1586
    - Intellectual Disability: 8035
      - X-Linked Mental Retardation: 272
        X-Linked 3 Mental Retardation: 3
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Nervous System Heredodegenerative Disorders: 63
    - X-Linked Mental Retardation: 272
      - X-Linked 3 Mental Retardation: 3
  - X-Linked Genetic Diseases: 42
    - X-Linked Mental Retardation: 272
      - X-Linked 3 Mental Retardation: 3

Related Diseases

1.	X-Linked Mental Retardation (Mental Retardation, X Linked)
2.	Parkinsonian Disorders (Parkinsonism)
3.	early onset with mental retardation Parkinsonism

Experts

1.	Che, Chengchuan: 1 article (10/2021)
2.	Gong, Zhijin: 1 article (10/2021)
3.	Li, Xiaona: 1 article (10/2021)
4.	Liu, Jinfeng: 1 article (10/2021)
5.	Su, Tao: 1 article (10/2021)
6.	Sun, Ping: 1 article (10/2021)
7.	Yang, Ge: 1 article (10/2021)
8.	Bravo-Santano, Natalia: 1 article (11/2019)
9.	Gil, Jose A: 1 article (11/2019)
10.	Letek, Michal: 1 article (11/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to X-Linked 3 Mental Retardation:

1.	MicroRNAs (MicroRNA)IBA 02/01/2003 - "Interestingly the gene locus of one miRNA, miR-175, is a candidate region for two neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). "
2.	Thioredoxin-Disulfide ReductaseIBA 10/22/2021 - "Recombinant Mrx3 not only catalytically reduced the disulfide bonds in ribonucleotide reductase (RNR), insulin and 5,5'-dithiobis-(2-nitro-benzoicacid) (DTNB), but also reduced the mixed disulphides between mycothiol (MSH) and substrate, which was exclusively linked to the thioredoxin reductase (TrxR) electron transfer pathway by a dithiol mechanism. "
3.	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 10/22/2021 - "Recombinant Mrx3 not only catalytically reduced the disulfide bonds in ribonucleotide reductase (RNR), insulin and 5,5'-dithiobis-(2-nitro-benzoicacid) (DTNB), but also reduced the mixed disulphides between mycothiol (MSH) and substrate, which was exclusively linked to the thioredoxin reductase (TrxR) electron transfer pathway by a dithiol mechanism. "
4.	Oxidoreductases (Dehydrogenase)IBA 10/22/2021 - "Thus, we presented the first evidence that Mrx3 protected against various oxidative stresses by acting as a disulfide oxidoreductase behaving like Trx."
5.	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/15/2019 - "In contrast, only mrx1 was essential for the survival against high concentrations of nitric oxide, while mrx3 was not required for the resistance to hydrogen peroxide. "
6.	Melanocyte-Stimulating Hormones (MSH)IBA 10/22/2021 - "Recombinant Mrx3 not only catalytically reduced the disulfide bonds in ribonucleotide reductase (RNR), insulin and 5,5'-dithiobis-(2-nitro-benzoicacid) (DTNB), but also reduced the mixed disulphides between mycothiol (MSH) and substrate, which was exclusively linked to the thioredoxin reductase (TrxR) electron transfer pathway by a dithiol mechanism. "
7.	Insulin (Novolin)FDA Link 10/22/2021 - "Recombinant Mrx3 not only catalytically reduced the disulfide bonds in ribonucleotide reductase (RNR), insulin and 5,5'-dithiobis-(2-nitro-benzoicacid) (DTNB), but also reduced the mixed disulphides between mycothiol (MSH) and substrate, which was exclusively linked to the thioredoxin reductase (TrxR) electron transfer pathway by a dithiol mechanism. "
8.	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/15/2019 - "In contrast, only mrx1 was essential for the survival against high concentrations of nitric oxide, while mrx3 was not required for the resistance to hydrogen peroxide. "
9.	Dithionitrobenzoic Acid (Ellman's Reagent)IBA 10/22/2021 - "Recombinant Mrx3 not only catalytically reduced the disulfide bonds in ribonucleotide reductase (RNR), insulin and 5,5'-dithiobis-(2-nitro-benzoicacid) (DTNB), but also reduced the mixed disulphides between mycothiol (MSH) and substrate, which was exclusively linked to the thioredoxin reductase (TrxR) electron transfer pathway by a dithiol mechanism. "
10.	DisulfidesIBA 10/22/2021 - "Thus, we presented the first evidence that Mrx3 protected against various oxidative stresses by acting as a disulfide oxidoreductase behaving like Trx." 10/22/2021 - "Recombinant Mrx3 not only catalytically reduced the disulfide bonds in ribonucleotide reductase (RNR), insulin and 5,5'-dithiobis-(2-nitro-benzoicacid) (DTNB), but also reduced the mixed disulphides between mycothiol (MSH) and substrate, which was exclusively linked to the thioredoxin reductase (TrxR) electron transfer pathway by a dithiol mechanism. "