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Basal Laminar Drusen

Also Known As:

Drusen of Bruch Membrane; Drusen, Cuticular; Drusen, Early Adult-Onset, Grouped

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Macular Degeneration (Age-Related Maculopathy)
2.	Choroidal Neovascularization
3.	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)
4.	Glomerulonephritis

Experts

1.	Boon, Camiel J F: 1 article (08/2012)
2.	Fauser, Sacha: 1 article (08/2012)
3.	Hoefsloot, Lies H: 1 article (08/2012)
4.	Hoyng, Carel B: 1 article (08/2012)
5.	Klaver, Caroline C W: 1 article (08/2012)
6.	Klevering, Jeroen: 1 article (08/2012)
7.	Schoenmaker-Koller, Frederieke: 1 article (08/2012)
8.	Smailhodzic, Dzenita: 1 article (08/2012)
9.	den Hollander, Anneke I: 1 article (08/2012)
10.	van de Ven, Johannes P H: 1 article (08/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Basal Laminar Drusen:

1.	Fluorescein (Funduscein)FDA LinkGeneric 06/01/2010 - "A 70-year-old man presented with adult vitelliform macular detachment and basal laminar drusen underwent fundus biomicroscopy, fundus fluorescein angiography and OCT-3. " 10/01/2007 - "To compare noninvasive autofluorescence (AF) photography with conventional fundus photography and fluorescein angiography (FA) in the detection of basal laminar drusen (BLD). " 03/01/1991 - "In three adolescents, suffering from membrano-proliferative glomerulonephritis type II, ophthalmoscopy and fluorescein angiography revealed retinal pigment epithelium lesions, referred to as basal laminar drusen. " 04/01/2012 - "These drusenoid deposits showed early hyperfluorescence in fluorescein angiography (FA) and intense staining in indocyanine green angiography similar to cuticular drusen (basal laminar drusen). "
2.	Retinaldehyde (Retinal)IBA 11/01/2009 - "Basal laminar drusen (BLD) is a rare retinal disorder that may be complicated with choroidal neovascularisation (CNV). " 01/01/1994 - "From 1986 through 1991, 23 twin pairs were recruited; 11 monozygotic and 2 dizygotic pairs had nonAMD retinal changes or no retinal abnormalities, 9 monozygotic pairs with AMD were all concordant, and 1 dizygotic pair was discordant for basal laminar drusen. "
3.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 03/01/1998 - "Indocyanine green angiography allows the visualization of basal laminar drusen and can easily differentiate choroidal neovascularization from acquired vitelliform degeneration." 03/01/1998 - "The aim of this case report is to describe the indocyanine green angiographic features of basal laminar drusen and pseudo-vitelliform material and to evaluate the role of ICG angiography in differentiating new choroidal vessels from vitelliform macular degeneration. " 03/01/1998 - "[Indocyanine green angiography of basal laminar drusen in the retinal pigment epithelium associated with vitelliform macular degeneration]." 04/01/2012 - "These drusenoid deposits showed early hyperfluorescence in fluorescein angiography (FA) and intense staining in indocyanine green angiography similar to cuticular drusen (basal laminar drusen). "
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/01/2009 - "To determine whether vascular endothelial growth factor (VEGF) mediates the leakage in basal laminar drusen (BLD)-associated vitelliform macular detachment (VMD) and whether VEGF blockade can improve visual function in affected eyes. " 01/01/2009 - "Vitelliform macular detachment associated with Basal laminar drusen is unresponsive to vascular endothelial growth factor blockade."
5.	LectinsIBA 02/01/2000 - "Both basal laminar drusen and drusen associated with age-related macular degeneration are bound by the lectins Ricinis communis agglutinin and Arachis hypogea agglutinin (after neuraminidase digestion) and by antivitronectin, anti-HLA-DR, anti-serum amyloid P, and anti-C5 antibodies, but not by antibodies directed against basement membrane-associated heparan sulfate proteoglycan, laminin, fibrinogen, or collagen type IV. These data support the notion that cuticular or basal laminar drusen are similar to, and perhaps indistinguishable from, drusen associated with age-related macular degeneration and are not nodular or diffuse thickenings of Bruch membrane, as previously suggested. "
6.	Collagen Type IV (Type IV Collagen)IBA 02/01/2000 - "Both basal laminar drusen and drusen associated with age-related macular degeneration are bound by the lectins Ricinis communis agglutinin and Arachis hypogea agglutinin (after neuraminidase digestion) and by antivitronectin, anti-HLA-DR, anti-serum amyloid P, and anti-C5 antibodies, but not by antibodies directed against basement membrane-associated heparan sulfate proteoglycan, laminin, fibrinogen, or collagen type IV. These data support the notion that cuticular or basal laminar drusen are similar to, and perhaps indistinguishable from, drusen associated with age-related macular degeneration and are not nodular or diffuse thickenings of Bruch membrane, as previously suggested. "
7.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 02/01/2000 - "Both basal laminar drusen and drusen associated with age-related macular degeneration are bound by the lectins Ricinis communis agglutinin and Arachis hypogea agglutinin (after neuraminidase digestion) and by antivitronectin, anti-HLA-DR, anti-serum amyloid P, and anti-C5 antibodies, but not by antibodies directed against basement membrane-associated heparan sulfate proteoglycan, laminin, fibrinogen, or collagen type IV. These data support the notion that cuticular or basal laminar drusen are similar to, and perhaps indistinguishable from, drusen associated with age-related macular degeneration and are not nodular or diffuse thickenings of Bruch membrane, as previously suggested. "
8.	Complement Factor H (Factor H)IBA 08/01/2012 - "Clinical evaluation of 3 families with basal laminar drusen caused by novel mutations in the complement factor H gene." 08/01/2012 - "To identify novel complement factor H (CFH) gene mutations and to specify the clinical characteristics in patients with basal laminar drusen (BLD), a clinical subtype of age-related macular degeneration. "
9.	Retinal Pigments (Pigments, Visual)IBA 10/15/1993 - "Membranoproliferative glomerulonephritis type II is specifically associated with the presence of dense deposits in the basement membrane of Bruch's membrane, which result in lesions similar to basal laminar drusen, exudative drusen, and retinal pigment epithelial detachments. "
10.	Polysaccharides (Glycans)IBA 06/01/2010 - "Basal laminar drusen and soft drusen have similar glycan composition."

Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy) 11/01/2009 - "Photodynamic therapy for choroidal neovascularisation secondary to basal laminar drusen."