Autoimmune Hypothyroidism

Thyroiditis that occurs in Hashimoto Disease and is characterized by Hashimoto struma, thyroid autoantibodies, an abnormal small iodinated protein in patient's serum, and a thyroid BASEMENT MEMBRANE defect. OMIM: 140300

Also Known As:

Networked: 229 relevant articles (4 outcomes, 25 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
2.	Hyperthyroidism
3.	Graves Ophthalmopathy
4.	Addison Disease (Addison's Disease)
5.	Acute Kidney Injury (Acute Renal Failure)

Experts

1.	Krysiak, Robert: 9 articles (10/2022 - 01/2011)
2.	Knudsen, Nils: 9 articles (10/2016 - 06/2005)
3.	Laurberg, Peter: 9 articles (10/2016 - 01/2002)
4.	Okopień, Bogusław: 7 articles (10/2022 - 06/2017)
5.	Carlé, Allan: 7 articles (10/2016 - 01/2006)
6.	Ovesen, Lars: 7 articles (10/2016 - 06/2005)
7.	Pedersen, Inge Bülow: 7 articles (10/2016 - 01/2006)
8.	Perrild, Hans: 7 articles (10/2016 - 06/2005)
9.	Kowalcze, Karolina: 5 articles (10/2022 - 11/2020)
10.	Weetman, A P: 5 articles (02/2006 - 09/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Autoimmune Hypothyroidism:

1.	AntibodiesIBA 10/13/2023 - "We tested thyroid function and thyroid antibodies and performed an ophthalmologic examination and neck ultrasound in two patients with autoimmune hypothyroidism converted to GD during a follow-up of several years. " 01/01/2020 - "We found that vit-B12 deficiency and vit-D deficiency were associated with autoimmune hypothyroidism, and that there was a negative correlation between vit-B12 and vit-D levels and anti-TPO antibodies in these patients. " 10/15/2019 - "Anti-Beta2glycoprotein I (anti-β2GPI) and anticardiolipin (aCL Ab) antibodies (the most clinically relevant aPL) were detected by immunoenzymatic assay (ELISA), in the amniotic fluid (AF) of 167 women with physiological and complicated common pregnancy conditions, sharing an aberrant implantation process, such as recurrent pregnancy loss (RPL), autoimmune hypothyroidism (ahT) and smoking. " 01/01/2016 - "Autoimmune hypothyroidism is known to be caused by immune responses related to the thyroid gland and its immunological feature includes presence of autoimmune antibodies. " 11/01/2015 - "She also had autoimmune hypothyroidism as suggested by raised TSH and positive anti-TPO antibodies. "
2.	Thyroxine (Levothyroxine)FDA LinkGeneric 01/01/1992 - "The administration of L-thyroxine at a dose of 2 micrograms/kg/day effectively eradicated all symptoms of the disease and led to the normalization of blood serum T3 and T4 values in the majority of patients with autoimmune hypothyroidism. " 11/01/2020 - "The aim of this study was to investigate whether macroprolactinemia determines levothyroxine action on hypothalamic-pituitary-thyroid axis activity and thyroid antibody titers in women with autoimmune hypothyroidism. " 11/01/2020 - "Macroprolactinemia Attenuates the Impact of Levothyroxine on Hypothalamic-Pituitary-Thyroid Axis Activity and Thyroid Autoimmunity in Women With Autoimmune Hypothyroidism." 10/17/2020 - "For decades, the focus of managing autoimmune hypothyroidism has been on thyroxine replacement. " 02/26/2020 - "A 42-year-old lady with longstanding autoimmune hypothyroidism was treated with thyroxine but in varying dosage, because TFTs, showing high Free T4 (FT4) and normal TSH levels, were discordant. "
3.	Thyroid HormonesIBA 04/01/2010 - "The main objective of our observation is to report a case of acute renal failure revealing an autoimmune hypothyroidism in which thyroid hormone substitution led to a significant improvement in muscular, thyroid and renal disorders." 05/01/2014 - "We report a case of Pityriasis Rubra Pilaris associated with autoimmune hypothyroidism which presented rapid and complete response after thyroid hormone replacement, without any association with other systemic treatment. " 12/01/1995 - "Because some patients with chronic urticaria and autoimmune hypothyroidism have had clinical resolution with thyroid hormone replacement, we investigated the effect of thyroid hormone in euthyroid patients with chronic urticaria and thyroid autoimmunity. " 06/01/2023 - "Exogenous thyroid hormone replacement therapy rapidly resolved the facial inflammation associated with this type of autoimmune hypothyroidism." 06/01/2006 - "In patients with autoimmune hypothyroidism, one should be aware of the possible presence of a TSH-secreting pituitary adenoma when TSH levels do not adequately suppress in the face of high doses of L-T4 replacement therapy and elevated serum thyroid hormone levels."
4.	SeleniumIBA 09/01/2016 - "Finally, to look into the possible role of selenium supplementation on oxidative stress in autoimmune hypothyroidism. " 11/01/2015 - "The prevalence of pathological thyroid conditions (hypothyroidism, subclinical hypothyroidism, autoimmune thyroiditis, and enlarged thyroid) was significantly lower in the adequate-selenium county than in the low-selenium county (18.0 vs 30.5%; P < .001). " 04/30/2013 - "Selenium may have beneficial effects on autoimmune hypothyroidism and on Graves' orbitopathy, but the effects of selenium on Graves' hyperthyroidism is unknown.We" 01/01/2018 - "Selenium supplementation may help to reduce the levels of antibodies in patients with autoimmune hypothyroidism." 01/01/2018 - "In a randomized clinical trial, 70 patients with autoimmune hypothyroidism randomly divided into two groups of 35 each, the first group was treated with oral selenium treatment with levothyroxine (LT4) and to the second group along with LT4, placebo was also prescribed. "
5.	FlavoproteinsIBA 09/01/2000 - "The frequencies of flavoprotein antibodies were significantly greater than controls (P-value < 0.05) for patients with systemic lupus erythematosus (P = 0.02), but not for patients with either Addison's disease (P = 0.05), pretibial myxoedema (P = 0.13), Graves' hyperthyroidism (P = 0.07), autoimmune hypothyroidism (P = 0.06) or thyroid-associated ophthalmopathy (P = 0.24). "
6.	Vitamin DFDA LinkGeneric 11/12/2021 - "Low vitamin D levels are associated with autoimmune hypothyroidism. " 08/01/2020 - "Vitamin D in Hypothyroid Patients and Association between Vitamin D and Anti-TPO in Autoimmune Hypothyroidism." 03/20/2020 - "Although in many studies, the relationship between autoimmune hypothyroidism (Hashimoto) and Vitamin D deficiency was shown, no research has been performed on the role of vitamin D in non-autoimmune hypothyroidism. " 10/01/2017 - "A 9-year-old girl previously diagnosed with autoimmune hypothyroidism and vitamin D deficiency, presented with hypercalcemic pancreatitis after initiating vitamin D supplementation that lead to a diagnosis of probable sarcoidosis. " 10/01/2020 - "The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism. "
7.	AutoantibodiesIBA 06/01/2005 - "The aims of this study were to evaluate the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure, and to study the thyroid volume in subjects with subclinical autoimmune hypothyroidism. " 12/01/2018 - "The prevalence and functional significance of TSHR blocking autoantibodies (TBAb) in autoimmune hypothyroidism has been less well investigated compared to TSHR stimulating Ab. " 03/01/2009 - "We prospectively identified all patients with incident overt autoimmune hypothyroidism in a Danish population cohort, and 247 patients were invited to join a comprehensive program including thyroid ultrasonography and measurements of thyroid autoantibodies. " 07/01/1991 - "The method allows the calculation of a putative "biologically active autoantibody" level and analysis of these data confirm our earlier observation that the species of autoantibody found in autoimmune hypothyroidism are potentially more destructive than those found in other forms of AITD." 01/01/1997 - "In addition to thyroid autoantibody and TSH measurements, thyroid echography appears to be a sensitive tool in the identification of patients at risk of developing autoimmune hypothyroidism during long-term Li therapy."
8.	IodineIBA 01/01/2016 - "adults with high TPOAb (a marker of autoimmune hypothyroidism) and low iodine status, who may represent a vulnerable subgroup. " 01/01/2013 - "Prevention of autoimmune hypothyroidism by modifying iodine intake and the use of tobacco and alcohol is manoeuvring between Scylla and Charybdis." 09/01/1999 - "Iodine deficiency has been reported to facilitate the development of toxic nodular goitre, whereas a high iodine intake may increase the prevalence of autoimmune hypothyroidism. " 07/01/1997 - "The high prevalence of antibody positivity in old age is independent of the iodine supply, but iodine supply has a determining role in the development of autoimmune hypothyroidism in the aged. " 11/01/2015 - "Patients newly diagnosed with overt autoimmune hypothyroidism (n = 140) and controls free of thyroid disease (n = 560) recruited from the same population participated in a population-based study of The Danish Investigation of Iodine Intake and Thyroid Diseases (DanThyr). "
9.	Iodide Peroxidase (Deiodinase)IBA 01/01/2021 - "Association of Thyroid Peroxidase Gene Polymorphisms and Serum Anti- TPO Levels in Egyptian Patients with Autoimmune Hypothyroidism." 03/01/2014 - "Euthyroid thyroid peroxidase (TPO-Ab)-positive subjects are at risk for progression to subclinical and overt autoimmune hypothyroidism. " 08/01/2014 - "Associations were considered in all women, then separately in women with high (≥ 9 IU/mL) vs normal (<9 IU/mL) levels of thyroid peroxidase antibody (TPOAb), a marker of autoimmune hypothyroidism (Hashimoto's disease). " 10/01/2006 - "In order to detect the possible association between shift work and subclinical autoimmune hypothyroidism we investigated the prevalence of isolated anti-peroxidase thyroid (TPO) autoantibodies in 220 shift workers and in 422 day-time workers. " 04/15/2023 - "We used multinomial logistic regression to estimate the association between fluoride exposure and classification of either subclinical or primary hypothyroidism and considered maternal thyroid peroxidase antibody (TPOAb) status, a marker of autoimmune hypothyroidism, as an effect modifier. "
10.	Thyrotropin Receptors (Thyrotropin Receptor)IBA 09/01/1993 - "We investigated whether the associations between HLA alleles of patients with autoimmune hypothyroidism varied according to the presence or absence of TSH receptor-blocking antibody (TRBab). " 01/01/2020 - "Autoimmune hyperthyroidism is caused by stimulating TSH receptor antibodies (TSHR Ab), patients with autoimmune hypothyroidism may have blocking TSHR Ab. " 04/25/2018 - "Hyperthyroidism in an infant of a mother with autoimmune hypothyroidism with positive TSH receptor antibodies." 08/01/2001 - "Blocking antibodies against the TSH receptor are involved in the development of hypothyroidism in a subset of patients with autoimmune hypothyroidism. " 11/03/2020 - "While most autoimmune hypothyroidism is due to Hashimoto's disease, in her case, we suspect that her hypothyroidism is due to a switch of antibody dominance from thyroid stimulating hormone (TSH) receptor-stimulating antibody (TS Ab) to TSH receptor-blocking antibody (TB Ab). "

Therapies and Procedures

1.	Therapeutics 05/01/2023 - "The literature is scanty regarding reports of the use of combination immune checkpoint therapy in patients with pre-existing autoimmune hypothyroidism. " 09/01/2010 - "Autoimmune hypothyroidism in infancy is rare, but early recognition and therapy are essential to prevent neurologic damage and growth deficits. " 11/01/2008 - "We studied 141 patients with primary autoimmune hypothyroidism, adequately treated with LT4 monotherapy and participating in a randomized clinical trial comparing LT4 therapy with LT4-LT3 combination therapy. " 09/01/2007 - "She was receiving replacement therapy for autoimmune hypothyroidism. " 02/17/2001 - "Ultimately, he proved to suffer from autoimmune hypothyroidism; the anaemia was resolved by substitution therapy."
2.	Transplantation 01/01/2023 - "Protocol for a double-blinded randomised controlled trial to assess the effect of faecal microbiota transplantations on thyroid reserve in patients with subclinical autoimmune hypothyroidism in the Netherlands: the IMITHOT trial." 05/01/2006 - "The causes of post-transplantation autoimmune hypothyroidism are probably multiple. " 12/01/2022 - "She developed autoimmune hypothyroidism 5 months after transplantation and was treated with levo-thyroxine with a good response. "
3.	Thyroidectomy 01/01/2011 - "Plasma levels of NT-pro-BNP did not differ between patients with Graves' disease and toxic nodular goitre nor between patients with autoimmune hypothyroidism and hypothyroidism secondary to thyroidectomy. " 01/01/1981 - "A cause for the hypothyroidism (autoimmune thyroid disease, post-radioiodine, post-thyroidectomy or antithyroid drugs) was established in all but two cases. " 12/01/2007 - "This study investigated the effects of L-thyroxine replacement therapy on lipid profile and endothelial function after thyroidectomy in patients with overt transient non-autoimmune hypothyroidism. "
4.	Hematopoietic Stem Cell Transplantation 01/01/2022 - "Passenger Lymphocyte Syndrome and Autoimmune Hypothyroidism Following Hematopoietic Stem Cell Transplantation." 05/01/2006 - "We describe two pediatric patients who developed autoimmune hypothyroidism 2 years after unrelated allogeneic hematopoietic stem cell transplantation. "
5.	Gluten-Free Diet 01/01/2015 - "Osteoporosis reversibility in a patient with celiac disease and primary autoimmune hypothyroidism on gluten free diet--a case report."