Euthyroid Goiter

A common hereditary autosomal dominant disorder characterized by nodular enlargement of the THYROID GLAND. In MNG1, some individuals may also develop SERTOLI-LEYDIG CELL TUMORS, usually of the OVARY. Mutations in the DICER1 gene have been identified for MNG1. OMIM: 138800

Also Known As:

Networked: 227 relevant articles (2 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Graves Disease (Basedow Disease)
2.	Thyroiditis
3.	Nodular Goiter
4.	Goiter
5.	Hyperthyroidism

Experts

1.	Attanasio, Roberto: 1 article (09/2022)
2.	Brandenburg, Tim: 1 article (09/2022)
3.	Führer, Dagmar: 1 article (09/2022)
4.	Hegedüs, Laszlo: 1 article (09/2022)
5.	Herrmann, Ken: 1 article (09/2022)
6.	Nagy, EndreV: 1 article (09/2022)
7.	Papini, Enrico: 1 article (09/2022)
8.	Perros, Petros: 1 article (09/2022)
9.	Vardarli, Irfan: 1 article (09/2022)
10.	Weidemann, Frank: 1 article (09/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Euthyroid Goiter:

1.	Thyroxine (Levothyroxine)FDA LinkGeneric 11/01/2007 - "Euthyroid goiter is usually treated with THS-inhibiting doses of L-thyroxin (L-T4), which can have troublesome adverse effects. " 06/01/1989 - "We studied two groups of 15 and 19 patients with euthyroid goiter for a period of six months: the former were untreated, the latter received L-thyroxine. " 03/15/1986 - "The hypo- and euthyroid variants of "simple" goiter are treated with thyroxine. " 12/17/1983 - "Suppressive doses of thyroxine were on average 119 micrograms/day in patients with euthyroid goiter and 183 micrograms thyroxine per day in patients with total thyroid ablation. " 02/15/1980 - "Concentration of total thyroxine, normalized thyroxine ratio, T3-RIA, and Serum TSH before and 30 minutes after stimulation with 0,2 mg TRH i.v. in various forms of euthyroid goiter were determined. "
2.	Potassium Iodide (Pima)FDA Link 01/01/1994 - "Euthyroid goiter is an indication for a combined treatment with jodid and levothyroxine. " 01/01/2003 - "A comparative analysis of the efficacy of potassium iodide-200 in pregnant women with diffuse euthyroid goiter and its combination with L-thyroxine has shown that by the effect on lessening frequency of neonatal TTH over 5 iU/l the above schemes do not differ significantly, thyroid reduction is more prominent in pregnant women on thyroxine with potassium iodide. "
3.	PotassiumIBA 01/01/2003 - "A comparative analysis of the efficacy of potassium iodide-200 in pregnant women with diffuse euthyroid goiter and its combination with L-thyroxine has shown that by the effect on lessening frequency of neonatal TTH over 5 iU/l the above schemes do not differ significantly, thyroid reduction is more prominent in pregnant women on thyroxine with potassium iodide. "
4.	IodineIBA 02/01/2001 - "In an iodine-deficient population, 3420 patients with simple goiter, who were not taking supplemental iodine, were chosen for this study. " 05/01/2012 - "The tendency of decreasing of prevalence and primary morbidity of diffused euthyroid goiter is established which can be a result of mass iodine prevention in the region. " 01/01/1998 - "TcTUs is constantly low in patients with euthyroid goiter, independent of the iodine excretion value. " 01/01/1997 - "Exclusion criteria were age above 35 years, known thyroid illness except simple goiter, application of x-ray contrast medium within the last 6 months or other known exposure to high doses of iodine. " 06/01/1996 - "We measured the 127I distribution within tyroid tissue to find out where intrathyroid iodine was deposited during iodine treatment in eight Tunisian female patients (aged 33-58 yr) with endemic euthyroid goiter. "
5.	Hormones (Hormone)IBA 04/01/1980 - "The authors concluded that the euthyroid goiter is characterized by a slightly impaired hormone synthesis in the rough endoplasmic reticulum, a damaged mechanism of hormone transport within the cell and respiratory disturbances of the thyreocyte." 01/01/1980 - "We conclude that all patients with euthyroid goiter after bilateral subtotal thyrectomy should receive hormone substitution because they are at high risk to develop recurrency. " 11/04/1983 - "[Hormone therapy of euthyroid goiter]." 08/04/1953 - "[Proposals for the therapy of simple goiter with pituitary thyrotropic hormone]." 11/01/1975 - "A determination was made of the hormone-forming capacity of the thyroid gland in pregnent women under conditions of goiter endemic at various periods of pregnancy by trimesters (123-in healthy pregnant women, 206-with euthyroid goiter of the I degree, 271-or II degree, 90-of the II degree, and 4-of the IV degree). "
6.	ThyroglobulinFDA Link 08/01/2001 - "Here we report a study of 50 cases diagnosed as having nonendemic simple goiter, and found 1 case with a large heterozygous deletion within the thyroglobulin gene. " 08/01/2001 - "We have previously demonstrated that some cases of endemic and nonendemic simple goiter are associated with a mutation within exon 10 of the thyroglobulin gene. " 08/01/2001 - "Monoallelic deletion in the 5' region of the thyroglobulin gene as a cause of sporadic nonendemic simple goiter." 10/01/1996 - "We have previously reported a point mutation in thyroglobulin exon 10 associated with nonendemic simple goiter. " 10/01/1957 - "[Thyroglobulin in therapy of simple goiter]."
7.	Thyroid HormonesIBA 01/01/2023 - "Adult Borealin +/- mice exhibited euthyroid goiter and defect in thyroid hormone synthesis. " 03/01/2014 - "In a prospective study on 28 patients and controls, we examined serum TSH and thyroid hormones before hemithyroidectomy and 1, 3, 6 and 12 months after hemithyroidectomy for benign euthyroid goiter. " 03/17/1984 - "as an aid in deciding whether to treat a simple goiter by thyroid hormone administration or surgery)." 05/10/1981 - "[Partial resistance to thyroid hormones in a patient with a euthyroid goiter (author's transl)]." 06/01/1976 - "27 subjects with a negative TRH test were selected among patients with euthyroid goiter treated by thyroid hormones. "
8.	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 12/15/1968 - "V. The dynamic study of thyroid function by thyrotropin stimulation in a group of patients thyroidectomized for hyperfunctioning syndromes and in a group thyroidectomized for simple goiter]." 07/01/1983 - "The blood calcitonine concentration decreases in patients with euthyroid goiter in the presence of the normal or reduced thyrotropin level, indicating thyrotropin-calcitonine relationships. " 07/01/1975 - "Thyroid-stimulating hormone levels in idiopathic euthyroid goiter." 03/01/2016 - "Compared with the persistent simple goiter group, the HT group had greater FH (54.8% vs 23.6%) and unchanged or increasing goiter size (89.3% vs 71.8%), and the iso-NAHT group had a higher proportion of patients within the upper tertile range of baseline thyrotropin levels (71.8% vs 24.9%) and unchanged or increasing goiter size (86.8% vs 71.8%; all P < .05). " 07/01/2005 - "Causes of goiter were nontoxic multinodular goiter (325 patients, 51.3%); toxic multinodular goiter (151 patients, 23.8%); solitary thyroid nodule (62 patients, 9.8%); toxic adenoma (32 patients, 5.0%); Graves' disease (27 patients, 4.3%); Hashimoto's thyroiditis (25 patients, 3.9%); simple goiter (8 patients, 1.3%); thyroiditis (3 patients, 0.5%); and thyroid-stimulating hormone-secreting pituitary adenoma (1 patient, 0.2%). "
9.	CalciumIBA 01/01/1983 - "The blood calcium and calcitorim levels were not changed in males and females with endemic euthyroid goiter in comparison with those of 19 healthy controls. " 03/01/1972 - "[Calcium and inorganic phosphorus metabolism in diffuse toxic and nodular euthyroid goiter]." 01/01/1983 - "The blood calcitonin and calcium content was studied in 38 patients with thyrotoxicosis, 20 subjects with endemic euthyroid goiter and 7 persons with primary hypothyrosis. " 01/01/2010 - "An analysis of results of surgical treatment of 50 patients aged from 16 to 75 years with different diseases of the thyroid has shown that the frequency of decrease of the level of calcium and parathormone becomes less in the row: diffuse toxic goiter, cancer of the thyroid gland, polynodous euthyroid goiter. " 01/01/1989 - "Although the levels of serum and urinary calcium and magnesium appear normal in adult subjects with simple goiter, decreased levels of the circulating parathormone were confirmed in most cases. "
10.	Triiodothyronine (Liothyronine)FDA LinkGeneric 12/31/1968 - "VI. The dynamic study of thyroid function with the L-triiodothyronine blocking rest in a group of subjects thyroidectomized for hyperfunctioning syndromes and in a group thyroidectomized for simple goiter]." 03/01/1984 - "[Intermittent use of thyroidin and triiodothyronine following surgical treatment of nodular euthyroid goiter]." 06/20/1970 - "[Euthyroid goiter with iodination defect and predominant formation of triiodothyronine, as a new form of iodine malutiligation]." 01/01/1986 - "Thyroglobulin (Tg), thyroxine (T4), and triiodothyronine (T3) were detected by the immunoperoxidase method in 51 cases of the following thyroid diseases: euthyroid goiter, Basedow's disease, Hashimoto's thyroiditis, folliculo-papillary carcinoma, follicular carcinoma, anaplastic carcinoma, and medullary carcinoma. "

Therapies and Procedures

1.	Thyroidectomy 12/01/1999 - "The aim of this study was to compare the experiences and results achieved by a single surgeon using total thyroidectomy and partial exeresis in the treatment of uni- and multinodular euthyroid goiter. " 12/01/1983 - "Study of the pituitary-thyroid axis in euthyroid goiter after partial thyroidectomy." 06/01/2023 - "On the other hand, indications for single-stage total thyroidectomy must be limited and ensure proximity between the patient's home and a healthcare structure with a platform adapted to the pathology necessitating surgical intervention (non-plunging euthyroid goiter). " 06/01/2002 - "[How to prevent surgical morbidity after a total thyroidectomy for a multinodular euthyroid goiter?]." 12/01/1999 - "[Total thyroidectomy in surgical treatment of euthyroid goiter]."
2.	Therapeutics 02/15/2009 - "[Influence of genetic factors on the result of therapy for diffuse euthyroid goiter]." 08/19/2000 - "[Diagnosis and therapy of patients with euthyroid goiter]." 08/15/1990 - "Suppressive therapy of euthyroid goiter was stopped by the treating physician in eleven patients (11%), in five permanently. " 01/01/1989 - "Postoperative recurrence of simple goiter and replacement therapy. " 12/17/1988 - "[Therapy of euthyroid goiter]."
3.	General Anesthesia 05/31/2023 - "The objective of this trial is to compare euthyroidectomy under local versus general anesthesia among patients with grade 1-2 uncomplicated euthyroid goiter in Uganda. " 05/01/1985 - "Grounds for indications for local and general anesthesia are given as well as for intrafascial resection of the thyroid as the operation of choice for nodular forms of euthyroid goiter."
4.	Radiotherapy 02/01/1969 - "Radiotherapy of simple goiter]." 04/22/1960 - "[Radiotherapy of euthyroid goiter with radioiodine I-131. " 01/01/1953 - "[The radiotherapy of simple goiter]." 10/06/1948 - "Three hundred nineteen simple goiter vessels in the biella area treated with radiotherapy." 07/01/1995 - "The diagnosis was made as a result of evaluation and treatment of a thyroid nodule (4), diffuse thyroid enlargement with thyrotoxicosis (2), and a simple goiter in a patient with a prior history of radiation treatment for facial acne. "
5.	Anesthesia 05/01/1998 - "[Comparative evaluation of variants of anesthesia in patients with euthyroid goiter]." 09/01/1964 - "[ON ANESTHESIA IN STRUMECTOMY IN THYROTOXICOSIS AND EUTHYROID GOITER]." 05/04/1957 - "[Experiences & results obtained with long-acting barbiturate anesthesia in surgery of euthyroid goiter, thyrotoxicosis & Basedow's disease]."