Acquired Partial Lipodystrophy

Lipodystrophy characterized by the gradual onset of bilaterally symmetrical loss of subcutaneous fat from the face, neck, upper extremities, thorax, and abdomen, in the 'cephalocaudal' sequence, sparing the lower extremities. Patients are also more likely to have AUTOIMMUNE DISEASES. Most cases are sporadic, however, there may be genetic susceptibility associated with mutations in the LMNB2 gene. OMIM: 608709

Also Known As:

Networked: 33 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
2.	Acquired Partial Lipodystrophy
3.	Lipodystrophy
4.	Familial Partial Lipodystrophy (Dunnigan Syndrome)
5.	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)

Experts

1.	Corvillo, Fernando: 5 articles (06/2021 - 01/2018)
2.	López-Trascasa, Margarita: 5 articles (06/2021 - 01/2018)
3.	Araújo-Vilar, David: 3 articles (06/2021 - 01/2018)
4.	López-Lera, Alberto: 3 articles (06/2021 - 01/2018)
5.	Nozal, Pilar: 3 articles (06/2021 - 01/2019)
6.	Ceccarini, Giovanni: 2 articles (06/2021 - 10/2020)
7.	Santini, Ferruccio: 2 articles (06/2021 - 10/2020)
8.	Garrido, Sofía: 2 articles (10/2020 - 01/2018)
9.	Garg, Abhimanyu: 2 articles (02/2019 - 05/2002)
10.	Delyfer, Marie-Noëlle: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acquired Partial Lipodystrophy:

1.	AutoantibodiesIBA 01/01/2019 - "Other clinical situations where these autoantibodies have been observed include infections and autoimmune disorders such as systemic lupus erythematosus and acquired partial lipodystrophy. " 01/01/2018 - "Using a combination of immunochemical and cellular studies, we investigated the presence of anti-adipocyte autoantibodies in patients with AGL, acquired partial lipodystrophy, localized lipoatrophy due to intradermic insulin injections or systemic lupus erythematosus. " 10/01/2020 - "C3 hypocomplementemia and the presence of C3 nephritic factor (C3NeF), an autoantibody causing complement system over-activation, are common features among most patients affected by Barraquer-Simons syndrome (BSS), an acquired form of partial lipodystrophy. "
2.	Insulin (Novolin)FDA Link 07/01/2017 - "Temporary resolution of insulin requirement in acquired partial lipodystrophy associated with chronic graft-versus-host disease." 01/01/2018 - "Using a combination of immunochemical and cellular studies, we investigated the presence of anti-adipocyte autoantibodies in patients with AGL, acquired partial lipodystrophy, localized lipoatrophy due to intradermic insulin injections or systemic lupus erythematosus. "
3.	Complement System Proteins (Complement)IBA 05/01/2018 - "In this paper, we describe the connection between the complement system with the biology of the adipose tissue and its pathogenesis reflected from acquired partial lipodystrophy." 05/01/2018 - "Acquired partial lipodystrophy and C3 glomerulopathy: Dysregulation of the complement system as a common pathogenic mechanism." 06/21/2021 - "Complement overactivation has been reported in most patients with Barraquer-Simons syndrome (BSS), a rare form of acquired partial lipodystrophy. " 01/01/2019 - "Complement over-activation has been reported in most of the patients with acquired partial lipodystrophy (also called Barraquer-Simons Syndrome) and in some cases of the generalized variety of the disease (Lawrence Syndrome). " 10/01/2019 - "Although an initial diagnosis of acquired partial lipodystrophy was considered, a diagnosis of bilateral Parry-Romberg was favored for three main reasons: (a) lipoatrophy was confined to the face (b) imaging findings of enophthalmos and underlying white matter changes (c) laboratories showing absence of C3 nephritic factor and normal complement levels. "
4.	Retinaldehyde (Retinal)IBA 11/01/2015 - "Retinal changes in a patient with acquired partial lipodystrophy (Laignel-Lavastine and Viard Syndrome)." 02/01/2002 - "Retinal alterations in acquired partial lipodystrophy: a case report." 01/01/2022 - "We here report for the first time a documented progressive retinal atrophy associated with Barraquer-Simons syndrome. " 01/01/2022 - "To report a case of lifelong progressive retinal atrophic lesions in a patient with partial acquired lipodystrophy, that is, Barraquer-Simons syndrome. " 01/01/2022 - "LIFELONG PROGRESSIVE RETINAL ATROPHIC LESIONS IN A PATIENT WITH PARTIAL ACQUIRED LIPODYSTROPHY (BARRAQUER-SIMONS SYNDROME)."
5.	Complement C3 Nephritic FactorIBA 11/01/2014 - "Although C3 nephritic factor was shown in family members with acquired partial lipodystrophy, it did not segregate with the renal phenotype. " 10/01/2019 - "Although an initial diagnosis of acquired partial lipodystrophy was considered, a diagnosis of bilateral Parry-Romberg was favored for three main reasons: (a) lipoatrophy was confined to the face (b) imaging findings of enophthalmos and underlying white matter changes (c) laboratories showing absence of C3 nephritic factor and normal complement levels. " 10/01/2020 - "C3 hypocomplementemia and the presence of C3 nephritic factor (C3NeF), an autoantibody causing complement system over-activation, are common features among most patients affected by Barraquer-Simons syndrome (BSS), an acquired form of partial lipodystrophy. "
6.	LeptinIBA 07/01/2017 - "The patient was diagnosed with acquired partial lipodystrophy that did not require alternative therapies such as leptin or insulin-like growth factor 1." 05/01/2002 - "Therefore, we compared fasting serum concentrations of adiponectin and leptin, in 18 patients with congenital generalized lipodystrophy (CGL), 11 with acquired generalized lipodystrophy (AGL), 46 with familial partial lipodystrophy-Dunnigan variety (FPLD) and 18 with acquired partial lipodystrophy (APL) and studied their relationship to metabolic parameters. "
7.	Hyaluronic Acid (Hyaluronan)IBA 10/01/2019 - "Hyaluronic acid fillers for correcting midface volume deficit in Barraquer-Simons syndrome." 01/01/2019 - "Acquired partial lipodystrophy treated with poly-L-lactic acid and hyaluronic acid fillers: a case report."
8.	1-dodecylpyridoxal (PLD)IBA 06/21/2021 - "A 35-year-old woman with acquired partial lipodystrophy (PLD) and features of type 2 membranoproliferative glomerulonephritis (MPGN-II), presented with difficulty in her fine detailed vision over the past year. " 05/01/2013 - "To report a case of choroidal neovascularization (CNV) associated with acquired partial lipodystrophy (PLD). A 55-year-old woman with a known history of PLD presented with acute onset visual loss affecting her right eye and underwent investigations to diagnose the underlying pathology. Fluorescein angiography and time-domain optical coherence tomography demonstrated the presence of intraretinal edema consistent with CNV. "
9.	AdiponectinIBA 05/01/2002 - "Therefore, we compared fasting serum concentrations of adiponectin and leptin, in 18 patients with congenital generalized lipodystrophy (CGL), 11 with acquired generalized lipodystrophy (AGL), 46 with familial partial lipodystrophy-Dunnigan variety (FPLD) and 18 with acquired partial lipodystrophy (APL) and studied their relationship to metabolic parameters. "
10.	Lamin Type B (Lamin B)IBA 06/10/2007 - "Duplication in LMNB1 encoding lamin B1 causes autosomal dominant leukodystrophy and mutations in LMNB2 encoding lamin B2 are associated with acquired partial lipodystrophy. "

Therapies and Procedures

1.	Injections 01/01/2018 - "Using a combination of immunochemical and cellular studies, we investigated the presence of anti-adipocyte autoantibodies in patients with AGL, acquired partial lipodystrophy, localized lipoatrophy due to intradermic insulin injections or systemic lupus erythematosus. "
2.	Therapeutics 02/01/2019 - "The four main types of lipodystrophy, excluding antiretroviral therapy-induced lipodystrophy in HIV-infected patients, are congenital generalised lipodystrophy (CGL), familial partial lipodystrophy (FPLD), acquired generalised lipodystrophy (AGL) and acquired partial lipodystrophy (APL). " 05/01/2007 - "This review focuses on new information regarding the pathophysiology of dense deposit disease, its appearance histopathologically, its relationship to other diseases including macular degeneration and acquired partial lipodystrophy and potential new therapies. " 02/13/2020 - "Partial abnormal fat distribution conditions such as HIV/HAART therapy-associated lipodystrophy, familial partial lipodystrophies, and acquired partial lipodystrophy frequently show a mixture of lipoatrophy and lipohypertrophy with metabolic dysfunction. "
3.	Perforator Flap 11/01/2012 - "One-stage transfer of 2 paddles of thoracodorsal artery perforator flap with vascular anastomoses for Barraquer-Simons syndrome." 05/01/2012 - "One-stage transfer of 2 paddles of thoracodorsal artery perforator flap with 1 pair of vascular anastomoses for Barraquer-Simons syndrome."
4.	Hematopoietic Stem Cell Transplantation 10/01/2013 - "Abnormal adipose tissue distribution with unfavorable metabolic profile in five children following hematopoietic stem cell transplantation: a new etiology for acquired partial lipodystrophy." 05/27/2019 - "Acquired partial lipodystrophy with metabolic disease in children following hematopoietic stem cell transplantation: a report of two cases and a review of the literature."
5.	Highly Active Antiretroviral Therapy (HAART) 02/13/2020 - "Partial abnormal fat distribution conditions such as HIV/HAART therapy-associated lipodystrophy, familial partial lipodystrophies, and acquired partial lipodystrophy frequently show a mixture of lipoatrophy and lipohypertrophy with metabolic dysfunction. "