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CE 224,535

structure in first source

Also Known As:

CE 224535; CE-224,535; CE-224535; CE224,535; CE224535

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bloom, Bradley J: 1 article (04/2012)
2.	Gupta, Pankaj: 1 article (04/2012)
3.	Ishaq, Saliha: 1 article (04/2012)
4.	Mebus, Charles A: 1 article (04/2012)
5.	Park, Won: 1 article (04/2012)
6.	Stock, Thomas C: 1 article (04/2012)
7.	Wang, Xin: 1 article (04/2012)
8.	Wei, Nathan: 1 article (04/2012)

Related Diseases

1.	Chronic Cough 01/01/2023 - "Finally, this article will outline published examples of the use of dogs to study the pharmacokinetics of P2X7 and P2X3 antagonists, and how they have contributed to the preclinical testing of antagonists to human P2X7, CE-224,535, and human P2X3, Gefapixant (AF-219, MK-7264) and Eliapixant (BAY, 1817080), with Gefapixant gaining recent approval for use in the treatment of refractory chronic cough in humans. "
2.	Nausea 04/01/2012 - "Treatment-emergent adverse events (AE) were reported by 62.3% (CE-224,535) and 55.3% (placebo) of patients; the most common AE were nausea (11.3%, CE-224,535; 4.3%, placebo) and diarrhea (7.5%, CE-224,535; 4.3%, placebo). "
3.	Diarrhea 04/01/2012 - "Treatment-emergent adverse events (AE) were reported by 62.3% (CE-224,535) and 55.3% (placebo) of patients; the most common AE were nausea (11.3%, CE-224,535; 4.3%, placebo) and diarrhea (7.5%, CE-224,535; 4.3%, placebo). "
4.	Rheumatoid Arthritis 04/01/2012 - "To evaluate efficacy and safety of CE-224,535, a selective P2X(7) receptor antagonist, versus placebo, in patients with active rheumatoid arthritis (RA) and inadequate response to methotrexate (MTX). " 04/01/2012 - "Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate."

Related Drugs and Biologics

1.	Gefapixant
2.	Purinergic P2X7 Receptors
3.	Methotrexate (Mexate)