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AZ 12253801

Also Known As:

AZ-12253801; AZ12253801

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - AZ 12253801: 3
  - Pyrimidines: 510
    - AZ 12253801: 3

Experts

1.	Aleksic, Tamara: 1 article (06/2015)
2.	Esashi, Fumiko: 1 article (06/2015)
3.	Gao, Shan: 1 article (06/2015)
4.	Lodhia, Kunal A: 1 article (06/2015)
5.	Macaulay, Valentine M: 1 article (06/2015)
6.	Aleksic, T: 1 article (11/2014)
7.	Chitnis, M M: 1 article (11/2014)
8.	Gao, S: 1 article (11/2014)
9.	Lodhia, K A: 1 article (11/2014)
10.	Macaulay, V M: 1 article (11/2014)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 06/15/2015 - "R0-3306 suppressed RAD51 focus formation consistent with HR attenuation, and sensitized prostate cancer cells to IGF-1R inhibition, with 2.4-fold reduction in AZ12253801 GI50 and 13-fold reduction in GI80. " 06/15/2015 - "We then tested effects of suppressing HR, and found that RAD51 depletion enhanced AZ12253801 sensitivity in PTEN wild-type prostate cancer cells but not in cells lacking functional PTEN. "
2.	Glioblastoma (Glioblastoma Multiforme) 11/06/2014 - "AZ12253801 radiosensitized DNA-dependent protein kinase (DNA-PK)-proficient but not DNA-PK-deficient glioblastoma cells, and did not radiosensitize DNA-PK-inhibited DU145 cells, suggesting that in the context of DSB repair, IGF-1R functions in the same pathway as DNA-PK. "
3.	Adenoma (Adenomas) 08/23/2011 - "Combined dosing with gefitinib and AZ12253801 similarly delayed the onset of symptoms, and at 200 days suppressed small intestinal tumourigenesis more effectively than either treatment alone (median small intestinal adenoma volume (47 mm(3) (comb) vs 248 mm(3) (AZ12253801), P=0.0003 and 47 mm(3) (comb) vs 123 mm(3) (gefitinib), P=0.0042, Mann-Whitney (two-sided) test). "

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