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tyrosyl-argininamide

has analgesic activity

Also Known As:

KTP-NH2; Tyr-Arg-NH2; kyotorphin-amide

Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - tyrosyl-argininamide: 4

Experts

1.	Heras, Montserrat: 4 articles (01/2020 - 01/2013)
2.	Bardaji, Eduard: 3 articles (01/2020 - 01/2013)
3.	Castanho, Miguel A R B: 3 articles (01/2020 - 01/2013)
4.	Lima, Carla: 2 articles (01/2017 - 01/2016)
5.	Lopes-Ferreira, Mônica: 2 articles (01/2017 - 01/2016)
6.	Perazzo, Juliana: 2 articles (01/2017 - 01/2016)
7.	Tavares, Isaura: 2 articles (01/2016 - 01/2013)
8.	Belo, Rita F: 1 article (01/2020)
9.	Coelho, Joana E: 1 article (01/2020)
10.	Costa-Coelho, Tiago: 1 article (01/2020)

Related Diseases

1.	Pain (Aches) 01/01/2013 - "Two kyotorphin derivatives, kyotorphin-amide (KTP-NH₂) and ibuprofen-KTP-NH₂ (IbKTP-NH₂) are promising alternatives to opioids: they trigger analgesia via an indirect opioid mechanism and are highly effective in several pain models following systemic delivery. "
2.	Memory Disorders (Memory Loss) 01/01/2020 - "Here, we evaluated if the blood-brain permeant KTP-derivative, KTP-NH2, when systemically administered, would be effective in preventing memory deficits in a sporadic AD animal model and if so, which would be the synaptic correlates of that action. " 01/01/2020 - "In the absence of KTP-NH2 treatment, Aβ-injected rats had clear memory deficits, as assessed through NOR or YM tests. " 01/01/2020 - "Importantly, these memory deficits were absent in Aβ-injected rats that had been treated with KTP-NH2, which scored in memory tests as control (sham i.c.v. injected) rats. "
3.	Inflammation (Inflammations) 01/01/2017 - "We conclude that KTP-NH2 has dual action: a glucocorticoid-mediated action, which is dominant in the full-fledged LPS-induced inflammation model, and a glucocorticoid-independent mechanism, which is predominant in models in which leukocyte rolling is stimulated but inflammation is not totally developed." 01/01/2016 - "Intravital microscopy data show that KTP-NH2 having a d-Tyr residue, KTP-NH2-DL, efficiently decreases the number of leukocyte rolling in a murine model of inflammation induced by bacterial lipopolysaccharide (LPS): down to 46% after 30 min with 96 μM KTP-NH2-DL. " 01/01/2017 - "KTP-NH2 does not inhibit the enkephalinases angiotensin-converting-enzyme and dipeptidyl-peptidase 3. Intravital microscopy showed that KTP-NH2 decreased the number of rolling leukocytes in a mouse model of inflammation induced by lipopolysaccharide (LPS). "

Related Drugs and Biologics

1.	Ibuprofen (Motrin)
2.	Opioid Analgesics (Opioids)
3.	kyotorphin (Tyr-Arg)
4.	Lipopolysaccharides
5.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
6.	Glucocorticoids
7.	Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
8.	salicylhydroxamic acid (SHAM)

Related Therapies and Procedures

1.	Analgesia