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4-(nitrooxy)butyl 2-(4-isobutylphenyl)propanoate

structure in first source

Also Known As:

NCX 320

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phenylpropionates
      - Ibuprofen: 5288
        4-(nitrooxy)butyl 2-(4-isobutylphenyl)propanoate: 1

Experts

1.	Azzoni, Emanuele: 1 article (09/2011)
2.	Brunelli, Silvia: 1 article (09/2011)
3.	Buono, Roberta: 1 article (09/2011)
4.	Cattaneo, Dario: 1 article (09/2011)
5.	Clementi, Emilio: 1 article (09/2011)
6.	Miglietta, Daniela: 1 article (09/2011)
7.	Pisa, Viviana: 1 article (09/2011)
8.	Sciorati, Clara: 1 article (09/2011)

Related Diseases

1.	Muscular Dystrophies (Muscular Dystrophy) 09/01/2011 - "A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy." 09/01/2011 - "Since inflammation and defects in nitric oxide generation are recognized key pathogenic events in muscular dystrophy, we have analysed the effects of a derivative of ibuprofen, NCX 320, belonging to the class of cyclooxygenase inhibiting nitric oxide donator (CINOD), in the α-sarcoglycan null mice, a severe mouse model of dystrophy. "
2.	Inflammation (Inflammations) 09/01/2011 - "Since inflammation and defects in nitric oxide generation are recognized key pathogenic events in muscular dystrophy, we have analysed the effects of a derivative of ibuprofen, NCX 320, belonging to the class of cyclooxygenase inhibiting nitric oxide donator (CINOD), in the α-sarcoglycan null mice, a severe mouse model of dystrophy. "

Related Drugs and Biologics

1.	Sarcoglycans (beta Sarcoglycan)
2.	Therapeutic Uses
3.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
4.	Nitric Oxide (Nitrogen Monoxide)
5.	Ibuprofen (Motrin)