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2- (3- (methylamino)phenyl)- 6- (pyrrolidin- 1- yl)quinolin- 4- one

antineoplastic; structure in first source

Also Known As:

2-(3-methylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-one; Smh-3 compound

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one: 1

Experts

1.	Chen, Ming-Hua: 1 article (05/2011)
2.	Chinag, Jo-Hua: 1 article (05/2011)
3.	Chou, Li-Chen: 1 article (05/2011)
4.	Hsu, Mei-Hua: 1 article (05/2011)
5.	Huang, Li-Jiau: 1 article (05/2011)
6.	Huang, Shih-Ming: 1 article (05/2011)
7.	Kuo, Sheng-Chu: 1 article (05/2011)
8.	Lee, Kuo-Hsiung: 1 article (05/2011)
9.	Lin, Hui-Yi: 1 article (05/2011)
10.	Tsai, Shih-Chang: 1 article (05/2011)

Related Diseases

1.

05/01/2011 - "In this study, we investigated the effects of 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) on viability, cell cycle and apoptotic cell death which occurred in different leukemia cell lines (HL-60, U937 and K562) in a dose- and time-dependent manner, but which did not obviously impair the viability of normal human umbilical vein endothelial cells (HUVEC) in vitro. "
05/01/2011 - "The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells."