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1- (5- chloro- 6- (trifluoromethoxy)- 1H- benzoimidazol- 2- yl)- 1H- pyrazole- 4- carboxylic acid

inhibits hypoxia-inducible factor prolyl hydroxylase; structure in first source

Also Known As:

JNJ 42041935; JNJ-42041935; JNJ42041935

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid: 4

Experts

1.	Botrè, Francesco: 1 article (02/2021)
2.	Comunità, Fabio: 1 article (02/2021)
3.	Mazzarino, Monica: 1 article (02/2021)
4.	Perretti, Ilaria: 1 article (02/2021)
5.	Stacchini, Carlotta: 1 article (02/2021)
6.	de la Torre, Xavier: 1 article (02/2021)
7.	Grover, S P: 1 article (01/2018)
8.	Humphries, J: 1 article (01/2018)
9.	Lyons, O T: 1 article (01/2018)
10.	Mazzone, M: 1 article (01/2018)

Related Diseases

1.	Inflammation (Inflammations) 06/01/2011 - "The results demonstrate that JNJ-42041935 is a new pharmacological tool, which can be used to investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia." 06/01/2011 - "JNJ-42041935 (100 μmol/kg, once a day for 14 days) was effective in reversing inflammation-induced anemia, whereas erythropoietin had no effect. " 06/01/2011 - "In addition, JNJ-42041935 was used to compare the effect of selective inhibition of PHD to intermittent, high doses (50 μg/kg i.p.) of an exogenous erythropoietin receptor agonist in an inflammation-induced anemia model in rats. "
2.	Anemia 06/01/2011 - "The results demonstrate that JNJ-42041935 is a new pharmacological tool, which can be used to investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia." 06/01/2011 - "JNJ-42041935 (100 μmol/kg, once a day for 14 days) was effective in reversing inflammation-induced anemia, whereas erythropoietin had no effect. " 06/01/2011 - "In addition, JNJ-42041935 was used to compare the effect of selective inhibition of PHD to intermittent, high doses (50 μg/kg i.p.) of an exogenous erythropoietin receptor agonist in an inflammation-induced anemia model in rats. "
3.	Hypoxia (Hypoxemia) 11/18/2023 - "We also report a distinct modulatory role for both JNJ-42041935 and roxadustat on fEPSP slope post hypoxia and OGD but not H2O2. " 06/01/2011 - "Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor." 11/18/2023 - "Both hypoxia and OGD induced a reduction in synaptic AMPA GluA2 subunits, the OGD effect being reversed by prior treatment with both JNJ-42041935 and roxadustat. " 02/13/2021 - "This article presents newly developed screening and confirmation analytical procedures to detect the misuse of nine prolyl-hydroxylase inhibitors of the hypoxia-inducible factor: daprodustat, desidustat, FG2216, IOX2, IOX4, JNJ-42041935, molidustat, roxadustat and vadadustat, targeting either the parent drugs and/or their main metabolite(s). "
4.	Thrombosis (Thrombus) 01/01/2018 - "Treatment with selective pan PHD inhibitors, AKB-4924 and JNJ-42041935, enhanced thrombus neovascularisation (P < 0.05), but had no significant effect on overall thrombus resolution. " 01/01/2018 - "Thrombus resolution was quantified in mice treated with pan PHD inhibitors AKB-4924 and JNJ-42041935 or inducible all-cell Phd2 knockouts by micro-computed tomography, 3D high frequency ultrasound or endpoint histology. "

Related Drugs and Biologics

1.	Erythropoietin
2.	Prolyl-Hydroxylase Inhibitors
3.	roxadustat
4.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
5.	Erythropoietin Receptors (Erythropoietin Receptor)
6.	AKB-4924
7.	vadadustat
8.	desidustat
9.	molidustat
10.	GSK1278863