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MHY336

Topoisomerase II Inhibitor; structure in first source

Also Known As:

5-hydroxy-7-(oxiran-2-ylmethoxy)-2-phenyl-4 H-chromen-4-one

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        MHY336: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        MHY336: 2

Experts

1.	Chung, Hae Young: 2 articles (03/2014 - 05/2011)
2.	Kim, Hyung Sik: 2 articles (03/2014 - 05/2011)
3.	Moon, Hyung Ryong: 2 articles (03/2014 - 05/2011)
4.	Chun, Pusoon: 1 article (03/2014)
5.	Kang, Jin Ah: 1 article (03/2014)
6.	Kang, Yong Jung: 1 article (03/2014)
7.	Kim, Dong Hwan: 1 article (03/2014)
8.	Kim, Nam Deuk: 1 article (03/2014)
9.	Lee, Sun Hwa: 1 article (03/2014)
10.	Sung, Bokyung: 1 article (03/2014)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 03/01/2014 - "In this study, we compared cytotoxicity, cell cycle distribution, and apoptosis on MHY336 treatment in three human colorectal carcinoma HCT116 cells: p53+/+ (p53‑wt), p53-/- (p53-null), and p21-/- (p21-null), as well as investigated the roles of p53 and p21 in cell death. "
2.	Prostatic Neoplasms (Prostate Cancer) 05/11/2011 - "An in vitro cell-based assay demonstrated that MHY336 significantly inhibited the proliferation of three prostate cancer cell lines, LNCaP, PC-3, and DU145 cells. " 05/11/2011 - "These results suggest that MHY336 is an attractive chemotherapeutic agent because of its topoisomerase II-mediated anti-tumour activity in human prostate cancer." 05/11/2011 - "A novel epoxypropoxy flavonoid derivative and topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells."
3.	Colonic Neoplasms (Colon Cancer) 03/01/2014 - "A novel oxiranylchromenone derivative, MHY336, induces apoptosis and cell cycle arrest via a p53- and p21-dependent pathway in HCT116 human colon cancer cells." 03/01/2014 - "Taken together, these results suggest that MHY336 could be a potential candidate to be used in chemoprevention and/or treatment of colon cancer. "

Related Drugs and Biologics

1.	Topoisomerase II Inhibitors
2.	Flavonoids
3.	Type II DNA Topoisomerases (Topoisomerase II)

Related Therapies and Procedures

1.	Chemoprevention