Phe(2)-Ile(3)-Hgn(4)-Orn(iPr)(8)- vasopressin

a vasopressin 1A receptor agonist; for treatment of vasodilatory hypotension

Also Known As:

vasopressin, Phe(2)-Ile(3)-Hgn(4)-Orn(iPr)(8)-; (Phe2,Ile3,Hgn4,Orn(iPr)8)vasopressin; 2-Phe-3-Ile-4-Hgn-8-Orn(iPr)-vasopressin; FE 202158; FE-202158; FE202158; vasopressin, phenylalanyl(2)-isoleucyl(3)-Hgn(4)-ornithyl(isopropyl)(8)-

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Laporte, Régent: 4 articles (07/2014 - 06/2011)
2.	Schteingart, Claudio D: 4 articles (07/2014 - 06/2011)
3.	Rivière, Pierre J-M: 3 articles (07/2014 - 06/2011)
4.	Wisniewski, Kazimierz: 3 articles (06/2012 - 06/2011)
5.	Enkhbaatar, Perenlei: 2 articles (07/2014 - 06/2012)
6.	Traber, Daniel L: 2 articles (07/2014 - 06/2012)
7.	Traber, Lillian D: 2 articles (07/2014 - 06/2012)
8.	La, Erin: 2 articles (06/2012 - 06/2011)
9.	Qi, Steve: 2 articles (06/2012 - 06/2011)
10.	Alagarsamy, Sudarkodi: 2 articles (07/2011 - 06/2011)

Related Diseases

1.	Sepsis (Septicemia) 07/01/2014 - "The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*." 07/01/2014 - "To determine if the selective vasopressin type 1a receptor agonist selepressin (FE 202158) is as effective as the mixed vasopressin type 1a receptor/vasopressin V2 receptor agonist vasopressor hormone arginine vasopressin when used as a titrated first-line vasopressor therapy in an ovine model of Pseudomonas aeruginosa pneumonia-induced severe sepsis. "
2.	Pneumonia (Pneumonitis) 07/01/2014 - "To determine if the selective vasopressin type 1a receptor agonist selepressin (FE 202158) is as effective as the mixed vasopressin type 1a receptor/vasopressin V2 receptor agonist vasopressor hormone arginine vasopressin when used as a titrated first-line vasopressor therapy in an ovine model of Pseudomonas aeruginosa pneumonia-induced severe sepsis. "
3.	Septic Shock (Toxic Shock Syndrome) 07/14/2011 - "Compound 45, FE 202158, is currently undergoing clinical trials in septic shock." 06/01/2011 - "Thus, FE 202158 seems suitable for treatment of conditions where V(1a)R activity is desirable but V(2)R activity is potentially deleterious, such as vasodilatory hypotension in septic shock. " 06/01/2012 - "Because von Willebrand factor is involved in coagulatory and inflammatory pathways during septic shock, future studies should clarify the role of the vasopressin type 2 receptor-mediated von Willebrand factor increase by arginine vasopressin and the potential benefit of selective vasopressin type 1a receptor-agonists like FE 202158." 06/01/2012 - "To compare the effects on von Willebrand factor release of the mixed vasopressin type 1a and type 2 receptor agonist arginine vasopressin and the selective vasopressin type 1a receptor agonist FE 202158, [Phe2,Ile3,Hgn4,Orn(iPr)8]vasopressin, at doses required for the treatment of septic shock. "
4.	Hypotension (Low Blood Pressure) 06/01/2011 - "Thus, FE 202158 seems suitable for treatment of conditions where V(1a)R activity is desirable but V(2)R activity is potentially deleterious, such as vasodilatory hypotension in septic shock. " 06/01/2011 - "Pharmacological characterization of FE 202158, a novel, potent, selective, and short-acting peptidic vasopressin V1a receptor full agonist for the treatment of vasodilatory hypotension."

Related Drugs and Biologics

1.	Vasopressin Receptors (Arginine Vasopressin Receptor)
2.	Arginine Vasopressin (Argipressin)
3.	Hormones (Hormone)
4.	von Willebrand Factor
5.	Vasopressins (Vasopressin)
6.	Phe(2)-Ile(3)-Hgn(4)-Orn(iPr)(8)- vasopressin

Related Therapies and Procedures

1.	Therapeutics