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conolidine

analgesic from the stem bark of Tabernaemontana divaricata; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - conolidine: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        conolidine: 2
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        conolidine: 2

Experts

1.	Baker, Mitchell W: 1 article (12/2021)
2.	Cornett, Elyse M: 1 article (12/2021)
3.	Edinoff, Amber N: 1 article (12/2021)
4.	Kaye, Adam M: 1 article (12/2021)
5.	Kaye, Alan D: 1 article (12/2021)
6.	Lawson, Jesse: 1 article (12/2021)
7.	Patel, Akash S: 1 article (12/2021)
8.	Sadegi, Kambiz: 1 article (12/2021)
9.	Wolcott, Christopher: 1 article (12/2021)
10.	Bohn, Laura M: 1 article (06/2011)

Related Diseases

1.	Chronic Pain 12/01/2021 - "Conolidine could represent the beginning of a new era of chronic pain management. " 12/01/2021 - "Conolidine: A Novel Plant Extract for Chronic Pain."
2.	Pain (Aches) 06/01/2011 - "Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain." 06/01/2011 - "Here, we describe the first de novo synthetic pathway to this exceptionally rare C5-nor stemmadenine natural product, the first asymmetric synthesis of any member of this natural product class, and the discovery that (±)-, (+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in an in vivo model of tonic and persistent pain."

Related Drugs and Biologics

1.	Non-Narcotic Analgesics (Analgesics, Non Narcotic)
2.	Plant Extracts
3.	stemmadenine