3,21-dihydroxypregna-5,7-dien-20-one
an antineoplastic agent; structure in first source
Also Known As:
21(OH)7DHP
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Bio-Agent Context: Research Results
Experts
Related Diseases
| 1. | Melanoma (Melanoma, Malignant)
01/01/2011
- " In summary, we have characterized for the first time products of UVB-induced conversion of 21(OH)7DHP and documented that these compounds have selective, inhibitory effects on melanoma cells." 01/01/2011
- " Moreover, 21(OH)7DHP and its derivatives inhibited proliferation of human epidermal HaCaT keratinocytes, albeit at a lower activity compared to melanoma cells. " 01/01/2011
- " Importantly, 21(OH)7DHP derivatives strongly inhibited the colony formation of human melanoma cells with 21(OH)pD being the most potent. " 01/01/2011
- " 3β,21-Dihydroxy-9β,10α-pregna-5,7-dien-20-one (21(OH)pL) and 21(OH)oxy-piT had higher potency against pigmented melanoma cells, while the EC(50) for compounds 21(OH)7DHP and (5Z,7E)-3β,21-dihydroxy-9,10-secopregna-5,7,10(19)-trien-20-one (21(OH)pD) were similar in both pigmented and non-pigmented cells. "
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