MRT67307

IKK (IκB(inhibitor of NF-κB (nuclear factor κB)) kinase) family inhibitor; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Pneumonia (Pneumonitis) 01/01/2023 - "Treatment with idronoxil, or the small molecule inhibitor MRT67307, suppresses TBK1/IKKε signalling and attenuates cellular and molecular lung inflammation in SARS-CoV-2-challenged mice. "
2.	Necrosis 02/15/2011 - "Using MRT67307, a novel inhibitor of IKKϵ/TBK1 (TANK {TRAF [TNF (tumour-necrosis-factor)-receptor-associated factor]-associated NF-κB activator}-binding kinase 1) and BI605906, a novel inhibitor of IKKβ, we demonstrate that two different signalling pathways participate in the activation of the IKK-related protein kinases by ligands that activate the IL-1 (interleukin-1), TLR (Toll-like receptor) 3 and TLR4 receptors. "

1.	Toll-Like Receptor 3
2.	Protein Kinases (Protein Kinase)
3.	Phosphotransferases (Kinase)
4.	Ligands
5.	Interleukin-1 (Interleukin 1)
6.	BI605906